Small leucine rich proteoglycans in host immunity and renal diseases

Small leucine rich proteoglycans in host immunity and renal diseases
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富含小亮氨酸的蛋白多糖在宿主免疫和肾脏疾病中的作用。

DOI：
10.1007/s12079-018-0489-8
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发表时间：
2018-10
期刊：
Journal of Cell Communication and Signaling
影响因子：
4.1
通讯作者：
Yi Gong
Yi Gong
中科院分区：
生物学2区
文献类型：
--
作者：
Wei Zou;Junhui Wan;Min Li;Juanjuan Xing;Qi Chen;Zhi Zhang;Yi Gong

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富含亮氨酸的小蛋白聚糖（SLRP），结构上由蛋白质核心和各种糖胺聚糖侧链组成，根据共同的结构和功能特性分为五类。SLRP除了是细胞外基质（ECM）的重要结构成分外，还参与了信号转导和宿主免疫反应的复杂网络。本文就SLRPs在宿主免疫中的作用作一综述。由于宿主免疫在肾脏疾病的发病机制中起着重要的作用，SLRPs在这组疾病中的作用也将进行讨论。
The small leucine rich proteoglycans (SLRPs), structurally consisting of protein cores and various glycosaminoglycan side chains, are grouped into five classes based on common structural and functional properties. Besides being an important structural component of extracellular matrix (ECM), SLRPs have been implicated in the complex network of signal transduction and host immune responses. The focus of this review is on SLRPs in host immunity. Because host immunity plays an important part in the pathogenesis of renal diseases, the role of SLRPs in this set of diseases will also be discussed.
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