Meta-analysis on the treatment of diabetic foot ulcers with autologous stem cells.
Meta-analysis on the treatment of diabetic foot ulcers with autologous stem cells.
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DOI：
10.1186/s13287-017-0683-2
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发表时间：
2017-10-16
影响因子：
7.5
通讯作者：
Gu Y
中科院分区：
文献类型：
--
作者：
Guo J;Dardik A;Fang K;Huang R;Gu Y
在过去的十年中，许多研究表明，自体干细胞治疗糖尿病下肢溃疡的治疗潜力。本研究的目的是对自体干细胞治疗糖尿病足溃疡（DFU）进行系统回顾和荟萃分析。检索策略包括Pubmed、EMBASE、Web of Science和科克伦图书馆数据库。测量的终点是DFU的愈合。从已发表的相关研究中筛选出6项符合条件的随机对照试验（RCT）研究，并进行荟萃分析。总体荟萃分析显示，干细胞给药显著有利于糖尿病溃疡愈合（平均差异（MD）0.52，95%置信区间（CI）0.38-0.65; p < 0.00001）。亚组分析表明，干细胞似乎对溃疡面积≥ 5 cm 2（MD 0.76，95% CI 0.55-0.97; p < 0.00001）和< 5 cm 2（MD 0.43，95% CI 0.31-0.54; p < 0.00001）的患者发挥了相似的有益作用。此外，干细胞对年龄≥ 70岁（MD 0.61，95% CI 0.14-1.08; p = 0.01）和< 70岁（MD 0.47，95% CI 0.35-0.58; p < 0.00001）的患者的影响相似。这项系统性综述和荟萃分析表明干细胞在DFU治疗中具有很好的作用。本文的综述将为进一步研究干细胞治疗的长期疗效和大规模随机对照试验铺平道路。
Over the last decade, many studies have indicated a therapeutic potential for treating diabetic lower extremity ulcers with autologous stem cells. The aim of the current study was to conduct a systematic review and meta-analysis of the treatment of diabetic foot ulcers (DFUs) with autologous stem cells. The search strategy included the Pubmed, EMBASE, Web of Science, and Cochrane’s Library databases. The endpoint measured was the healing of DFUs. Six eligible randomized controlled trial (RCT) studies were screened from related published studies and reviewed for meta-analysis. The overall meta-analysis showed that stem cell administration was significantly favorable for healing diabetic ulcers (mean difference (MD) 0.52, 95% confidence interval (CI) 0.38–0.65; p < 0.00001). Subgroup analyses indicated that stem cells seemed to exert similar beneficial effects on patients with ulcer size ≥ 5 cm2 (MD 0.76, 95% CI 0.55–0.97; p < 0.00001) and < 5 cm2 (MD 0.43, 95% CI 0.31–0.54; p < 0.00001). Furthermore, stem cells had similar effects on patients aged ≥ 70 years (MD 0.61, 95% CI 0.14–1.08; p = 0.01) and < 70 years (MD 0.47, 95% CI 0.35–0.58; p < 0.00001). This systematic review and meta-analysis suggests a promising role for stem cells in DFU treatment. This review will pave the way to further study on the long-term effects of stem cell-based therapy and large-scale RCTs.
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影响因子：
6
作者：
Skardal A;Mack D;Kapetanovic E;Atala A;Jackson JD;Yoo J;Soker S
通讯作者：
Soker S
影响因子：
7.4
作者：
Choudhery MS;Badowski M;Muise A;Pierce J;Harris DT
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影响因子：
2.4
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通讯作者：
Beckh, Karlheinz
影响因子：
5.1
作者：
Schaper, N. C.;Van Netten, J. J.;Bakker, K.
通讯作者：
Bakker, K.