Ultra wideband (0.5-16 kHz) MR elastography for robust shear viscoelasticity model identification.

Ultra wideband (0.5-16 kHz) MR elastography for robust shear viscoelasticity model identification.
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DOI:
10.1088/0031-9155/59/24/7717
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发表时间:
2014-12-21
影响因子:
3.5
通讯作者:
Royston TJ
Royston TJ
中科院分区:
工程技术2区
文献类型:
--
作者:
Liu Y;Yasar TK;Royston TJ

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软生物组织的粘弹性参数的变化通常与疾病、创伤或损伤的进展以及对治疗的反应相关。识别最合适的粘弹性模型,然后估计和监测该模型的相应参数可以提高对潜在组织结构变化的洞察。MR弹性成像(MRE)提供了一种定量测量组织粘弹性的方法。在作者之前的一项研究中[Mag. Res. Med. 70:479-89;2013。土井:10.1002/mrm.24495],使用MRE(当时前所未有的带宽)在200 Hz至7.75 kHz的频率范围内检查硅橡胶体模材料。六个粘弹性模型,包括四个整数阶模型和两个分数阶模型,适合宽带粘弹性数据(测量的存储和损耗模量作为频率的函数)。“分数Voigt”模型(弹簧和弹簧罐并联)表现出最佳拟合,并且当仅基于频带的一小部分来识别时,甚至能够很好地拟合整个频带。本文是该研究的扩展,具有更宽的频率范围,从500 Hz到16 kHz。此外,更多的分数阶粘弹性模型被添加到比较池中。据发现,增加的粘弹性模型的复杂性提供了只有边际改善“分数Voigt”模型。并且,分数阶模型再次显示出比具有同样多或更多拟合参数的整数阶粘弹性模型显著的改进。
Changes in the viscoelastic parameters of soft biological tissues often correlate with progression of disease, trauma or injury, and response to treatment. Identifying the most appropriate viscoelastic model, then estimating and monitoring the corresponding parameters of that model can improve insight into the underlying tissue structural changes. MR Elastography (MRE) provides a quantitative method of measuring tissue viscoelasticity. In a previous study of the authors [Mag. Res. Med. 70:479–89;2013. doi: 10.1002/mrm.24495], a silicone-based phantom material was examined over the frequency range of 200 Hz to 7.75 kHz using MRE, an unprecedented bandwidth at that time. Six viscoelastic models including four integer order models and two fractional order models, were fit to the wideband viscoelastic data (measured storage and loss moduli as a function of frequency). The “fractional Voigt” model (spring and springpot in parallel) exhibited the best fit and was even able to fit the entire frequency band well when it was identified based only on a small portion of the band. This paper is an extension of that study with a wider frequency range from 500 Hz to 16 kHz. Furthermore, more fractional order viscoelastic models are added to the comparison pool. It is found that added complexity of the viscoelastic model provides only marginal improvement over the “fractional Voigt” model. And, again, the fractional order models show significant improvement over integer order viscoelastic models that have as many or more fitting parameters.
DOI: 10.1088/0305-4470/28/23/012
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