Functional body composition and related aspects in research on obesity and cachexia: report on the 12th Stock Conference held on 6 and 7 September 2013 in Hamburg, Germany.
Functional body composition and related aspects in research on obesity and cachexia: report on the 12th Stock Conference held on 6 and 7 September 2013 in Hamburg, Germany.
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肥胖和恶病质研究中的功能性身体组成及相关方面：2013年9月6日至7日在德国汉堡举行的第12次股票会议报告。
DOI：
10.1111/obr.12187
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发表时间：
2014-08
期刊：
影响因子：
--
通讯作者：
Heymsfield SB
中科院分区：
文献类型：
--
作者：
Müller MJ;Baracos V;Bosy-Westphal A;Dulloo AG;Eckel J;Fearon KC;Hall KD;Pietrobelli A;Sørensen TI;Speakman J;Trayhurn P;Visser M;Heymsfield SB
第12届股票会议讨论了两种极端情况下的身体组成和相关功能，肥胖和癌症恶病质。“功能性身体组成”的概念将身体成分整合到将器官和组织的质量与相应的体内功能和代谢过程相关联的调节系统中。这个概念增加了对器官/组织质量和功能的理解，在代谢适应体重变化和疾病的背景下。在体重增加和减少的过程中，个体身体成分会发生相关变化，而器官和组织质量之间的关系是固定的。因此，对体重调节的理解涉及器官-组织调节的检查，而不是单个器官质量的检查。器官/组织质量之间的关系与细胞因子、激素和代谢物介导的器官和组织之间的相互作用相关，并由其解释，细胞因子、激素和代谢物与肥胖和癌症恶病质中观察到的体重、组成和功能变化相关。除了在中间代谢、细胞功能和炎症中的既定作用外，器官-组织串扰介质是身体组成及其随体重增加和减轻而变化的决定因素。第12届股票会议支持迈克尔股票的概念，获得新的见解，通过整合研究思路，从肥胖和癌症恶病质。会议报告提供了对身体组成和新陈代谢的深入了解。
The 12th Stock Conference addressed body composition and related functions in two extreme situations, obesity and cancer cachexia. The concept of “functional body composition” integrates body components into regulatory systems relating the mass of organs and tissues to corresponding in vivo functions and metabolic processes. This concept adds to an understanding of organ/tissue mass and function in the context of metabolic adaptations to weight change and disease. During weight gain and loss there are associated changes in individual body components while the relationships between organ and tissue mass are fixed. Thus, an understanding of weight regulation involves an examination of organ-tissue regulation rather than of individual organ mass. The between organ/tissue mass relationships are associated with and explained by cross-talk between organs and tissues mediated by cytokines, hormones, and metabolites that are coupled with changes in body weight, composition, and function as observed in obesity and cancer cachexia. In addition to established roles in intermediary metabolism, cell function and inflammation, organ-tissue cross-talk mediators are determinants of body composition and its’ change with weight gain and loss. The 12th Stock Conference supported Michael Stocks’ concept of gaining new insights by integrating research ideas from obesity and cancer cachexia. The conference presentations provide an in-depth understanding of body composition and metabolism.
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DOI：
10.1084/jem.20111020
发表时间：
2011-11-21
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Braun TP;Zhu X;Szumowski M;Scott GD;Grossberg AJ;Levasseur PR;Graham K;Khan S;Damaraju S;Colmers WF;Baracos VE;Marks DL
通讯作者：
Marks DL
影响因子：
2.9
作者：
Bortoluzzi, S;Scannapieco, P;Schiaffino, S
通讯作者：
Schiaffino, S
影响因子：
4
作者：
De Laet, C;Kanis, JA;Tenenhouse, A
通讯作者：
Tenenhouse, A
影响因子：
4
作者：
Bosy-Westphal, Anja;Braun, Wiebke;Mueller, Manfred J.
通讯作者：
Mueller, Manfred J.
影响因子：
82.9
作者：
Berg, AH;Combs, TP;Scherer, PE
通讯作者：
Scherer, PE