Combining radiotherapy and focused ultrasound for pain palliation of cancer induced bone pain; a stage I/IIa study according to the IDEAL framework.
Combining radiotherapy and focused ultrasound for pain palliation of cancer induced bone pain; a stage I/IIa study according to the IDEAL framework.
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联合放疗和聚焦超声缓解癌症引起的骨痛;根据IDEAL框架的I/IIa期研究。
DOI：
10.1016/j.ctro.2021.01.005
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发表时间：
2021-03
影响因子：
3.1
通讯作者：
Verkooijen HM
中科院分区：
文献类型：
--
作者：
Bartels MMTJ;Verpalen IM;Ferrer CJ;Slotman DJ;Phernambucq ECJ;Verhoeff JJC;Eppinga WSC;Braat MNGJA;van den Hoed RD;van 't Veer-Ten Kate M;de Boer E;Naber HR;Nijholt IM;Bartels LW;Bos C;Moonen CTW;Boomsma MF;Verkooijen HM
EBRT和MR-HIFU联合治疗是可行的，患者耐受性良好。EBRT和MR-HIFU联合治疗的临床结果是有希望的。联合治疗相对于标准EBRT的优越性需要在比较研究中进行评估。癌症引起的骨痛（CIBP）严重影响患者的生活质量。目前，标准治疗包括体外放射治疗（EBRT），约60%的患者疼痛缓解。磁共振引导的高强度聚焦超声（MR-HIFU）是一种很有前途的治疗CIBP的方式。进行了一项单组、R-IDEAL I/IIa期研究。在放射肿瘤科就诊的患者有症状性骨转移，在approximular骨骼，以及在骶骨和胸骨有资格入选。所有参与者均接受了EBRT，随后在4天内接受了MR-HIFU。评估安全性和可行性，并在完成联合治疗后监测疼痛评分4周。6例患者入组。中位年龄为67岁，中位病变直径为56.5 mm。在所有患者中，在EBRT后4天内计划并执行MR-HIFU治疗在逻辑上是可能的。所有患者对联合手术耐受良好。在完成联合治疗后7天，6例患者中有5例报告疼痛缓解，并在4周随访时稳定在60%。未发生治疗相关严重不良事件。这是首次将联合收割机EBRT与MR-HIFU相结合的研究。我们的研究结果表明，EBRT联合MR-HIFU一线治疗CIBP是安全可行的，患者耐受性良好。在疼痛缓解（时间）和生活质量方面优于标准EBRT，需要在比较（随机）研究中进行评价。
Combined treatment of EBRT and MR-HIFU is feasible and well tolerated by patients. Clinical outcomes of combined treatment of EBRT and MR-HIFU are promising. Superiority of combined treatment over standard EBRT needs to be evaluated in a comparative study. Cancer induced bone pain (CIBP) strongly interferes with patient’s quality of life. Currently, the standard of care includes external beam radiotherapy (EBRT), resulting in pain relief in approximately 60% of patients. Magnetic Resonance guided High Intensity Focused Ultrasound (MR-HIFU) is a promising treatment modality for CIBP. A single arm, R-IDEAL stage I/IIa study was conducted. Patients presenting at the department of radiation oncology with symptomatic bone metastases in the appendicular skeleton, as well as in the sacrum and sternum were eligible for inclusion. All participants underwent EBRT, followed by MR-HIFU within 4 days. Safety and feasibility were assessed, and pain scores were monitored for 4 weeks after completing the combined treatment. Six patients were enrolled. Median age was 67 years, median lesion diameter was 56,5 mm. In all patients it was logistically possible to plan and perform the MR-HIFU treatment within 4 days after EBRT. All patients tolerated the combined procedure well. Pain response was reported by 5 out of 6 patients at 7 days after completion of the combined treatment, and stabilized on 60% at 4 weeks follow up. No treatment related serious adverse events occurred. This is the first study to combine EBRT with MR-HIFU. Our results show that combined EBRT and MR-HIFU in first-line treatment of CIBP is safe and feasible, and is well tolerated by patients. Superiority over standard EBRT, in terms of (time to) pain relief and quality of life need to be evaluated in comparative (randomized) study.
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DOI：
10.1186/s40349-018-0117-3
发表时间：
2018-11-30
期刊：
JOURNAL OF THERAPEUTIC ULTRASOUND
影响因子：
--
作者：
Bertrand, Anne-Sophie;Iannessi, Antoine;Thyss, Antoine
通讯作者：
Thyss, Antoine
DOI：
10.1016/j.ijrobp.2003.10.006
发表时间：
2004-06-01
影响因子：
7
作者：
van der Linden, YM;Lok, JJ;Leer, JWH
通讯作者：
Leer, JWH
DOI：
10.1007/978-1-4419-1469-9_5
发表时间：
2012-01-01
期刊：
INTERVENTIONAL ONCOLOGY: A PRACTICAL GUIDE FOR THE INTERVENTIONAL RADIOLOGIST
影响因子：
--
作者：
ter Haar, Gail
通讯作者：
ter Haar, Gail
DOI：
10.1016/j.ijrobp.2016.03.032
发表时间：
2016-08-01
影响因子：
7
作者：
Westhoff, Paulien G.;Verdam, Mathilde G. E.;van der Linden, Yvette M.
通讯作者：
van der Linden, Yvette M.
DOI：
10.1016/j.ijrobp.2017.09.030
发表时间：
2018-01-01
影响因子：
7
作者：
Chi, Mau-Shin;Yang, Kai-Lin;Chi, Kwan-Hwa
通讯作者：
Chi, Kwan-Hwa