Hepatic STAMP2 decreases hepatitis B virus X protein-associated metabolic deregulation.
Hepatic STAMP2 decreases hepatitis B virus X protein-associated metabolic deregulation.
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DOI：
10.3858/emm.2012.44.10.071
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发表时间：
2012-10-31
影响因子：
12.8
通讯作者：
Cheong JH
中科院分区：
文献类型：
--
作者：
Kim HY;Cho HK;Yoo SK;Cheong JH
前列腺六跨膜蛋白2（STAMP 2）在将炎症和饮食来源的信号与全身代谢联系起来方面起着关键作用。STAMP 2由营养物/进食以及细胞因子如TNFα、IL-1β和IL-6诱导。在这里，我们证明了STAMP 2蛋白与B型肝炎病毒X蛋白（HBx）物理相互作用并降低其稳定性，从而抵消HBx诱导的肝脏脂质积累和胰岛素抵抗。STAMP 2抑制HBx介导的脂肪生成和脂肪生成基因的转录。此外，STAMP 2阻止了HBx诱导的介导肝脏胰岛素信号传导的IRS 1蛋白降解，以及恢复了胰岛素介导的对作为致凋亡基因的致凋亡酶表达的抑制。我们还证明了HBx和STAMP 2在HBx转基因小鼠中的相互表达。这些结果表明，肝STAMP 2拮抗HBx介导的肝细胞功能障碍，从而保护肝细胞免受HBV基因表达。
Six transmembrane protein of prostate 2 (STAMP2) plays a key role in linking inflammatory and diet-derived signals to systemic metabolism. STAMP2 is induced by nutrients/feeding as well as by cytokines such as TNFα, IL-1β, and IL-6. Here, we demonstrated that STAMP2 protein physically interacts with and decreases the stability of hepatitis B virus X protein (HBx), thereby counteracting HBx-induced hepatic lipid accumulation and insulin resistance. STAMP2 suppressed the HBx-mediated transcription of lipogenic and adipogenic genes. Furthermore, STAMP2 prevented HBx-induced degradation of IRS1 protein, which mediates hepatic insulin signaling, as well as restored insulin-mediated inhibition of gluconeogenic enzyme expression, which are gluconeogenic genes. We also demonstrated reciprocal expression of HBx and STAMP2 in HBx transgenic mice. These results suggest that hepatic STAMP2 antagonizes HBx-mediated hepatocyte dysfunction, thereby protecting hepatocytes from HBV gene expression.
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DOI：
10.1074/jbc.m111.259978
发表时间：
2011-08-26
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Shin HJ;Park YH;Kim SU;Moon HB;Park DS;Han YH;Lee CH;Lee DS;Song IS;Lee DH;Kim M;Kim NS;Kim DG;Kim JM;Kim SK;Kim YN;Kim SS;Choi CS;Kim YB;Yu DY
通讯作者：
Yu DY
影响因子：
8
作者：
Korkmaz, CG;Korkmaz, KS;Saatcioglu, F
通讯作者：
Saatcioglu, F
影响因子：
4.1
作者：
Kim, KyeongJin;Kim, Kook Hwan;Cheong, JaeHun
通讯作者：
Cheong, JaeHun
影响因子：
4.8
作者：
Moldes, M;Lasnier, F;Chambaut-Guérin, AM
通讯作者：
Chambaut-Guérin, AM
影响因子：
25.7
作者：
Yu, DY;Moon, HB;Lee, KK
通讯作者：
Lee, KK