Dynamics and Hierarchical Encoding of Non-compact Acoustic Categories in Auditory and Frontal Cortex

Dynamics and Hierarchical Encoding of Non-compact Acoustic Categories in Auditory and Frontal Cortex
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听觉和额叶皮层非紧凑声学类别的动力学和层次编码

DOI:
10.1016/j.cub.2020.02.047
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发表时间:
2020
期刊:
影响因子:
9.2
通讯作者:
Shamma, Shihab A.
Shamma, Shihab A.
中科院分区:
生物学1区
文献类型:
--
作者:
Yin, Pingbo;Strait, Dana L.;Radtke-Schuller, Susanne;Fritz, Jonathan B.;Shamma, Shihab A.

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分类感知是一种基本的认知功能,使动物能够灵活地将声音分配到行为相关的类别中。本研究探讨了声学类别表征的性质,他们出现在一个上升系列的雪貂听觉和额叶皮层领域,以及这种表示在被动听取任务相关的刺激和主动检索记忆,而从事学习分类任务的动态。雪貂进行了两个听觉Go-NoGo分类任务的训练,以区分两个非紧凑的声音类别(由音调或调幅噪声组成)。神经元的反应变得越来越明确,在更高的皮质领域,特别是在执行任务。动态的分类反应表现出级联自上而下的调制模式,最早开始在额叶皮层,随后流向下游的次级听觉皮层,其次是初级听觉皮层。在一个神经元亚群中,即使在被动听力条件下,分类反应也持续存在,这表明了对任务类别及其增强的分类边界的记忆。
Categorical perception is a fundamental cognitive function enabling animals to flexibly assign sounds into behaviorally relevant categories. This study investigates the nature of acoustic category representations, their emergence in an ascending series of ferret auditory and frontal cortical fields, and the dynamics of this representation during passive listening to task-relevant stimuli and during active retrieval from memory while engaging in learned categorization tasks. Ferrets were trained on two auditory Go-NoGo categorization tasks to discriminate two non-compact sound categories (composed of tones or amplitude-modulated noise). Neuronal responses became progressively more categorical in higher cortical fields, especially during task performance. The dynamics of the categorical responses exhibited a cascading top-down modulation pattern that began earliest in the frontal cortex and subsequently flowed downstream to the secondary auditory cortex, followed by the primary auditory cortex. In a subpopulation of neurons, categorical responses persisted even during the passive listening condition, demonstrating memory for task categories and their enhanced categorical boundaries.
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