Microglial Immunometabolism in Alzheimer's Disease.
Microglial Immunometabolism in Alzheimer's Disease.
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DOI：
10.3389/fncel.2020.563446
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发表时间：
2020
影响因子：
5.3
通讯作者：
Ulland TK
中科院分区：
文献类型：
--
作者：
Shippy DC;Ulland TK
阿尔茨海默病 (AD) 是一种神经退行性疾病，其特征是淀粉样蛋白-β (Aβ) 斑块和由过度磷酸化 tau 蛋白组成的神经原纤维缠结 (NFT)。为了响应 Aβ 和 tau 蛋白聚集，小胶质细胞（中枢神经系统 (CNS) 的主要先天免疫细胞）会促进 Aβ 和 tau 蛋白的清除，并导致损害神经元的神经炎症。小胶质细胞还执行多种其他功能，例如中枢神经系统内需要大量能量的突触修剪。葡萄糖似乎是主要能量来源，但小胶质细胞可以利用其他几种底物来产生能量，包括其他糖和酮体。最近的研究表明，包括巨噬细胞在内的免疫细胞代谢特征的变化对于控制其激活和效应功能非常重要。其他研究主要集中在代谢在神经元和星形胶质细胞功能中的作用，而直到最近，人们对小胶质细胞代谢的了解还相当少。考虑到许多神经系统疾病，例如与 AD 相关的神经变性，与慢性炎症和脑能量代谢的改变有关，因此假设小胶质细胞代谢在神经变性期间小胶质细胞的炎症反应中发挥重要作用。在这里，我们回顾一下小胶质细胞免疫代谢在 AD 中的作用。
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by amyloid-β (Aβ) plaques and the formation of neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau. In response to Aβ and tau aggregates, microglia, the primary innate immune cells of the central nervous system (CNS), facilitate Aβ and tau clearance and contribute to neuroinflammation that damages neurons. Microglia also perform a wide range of other functions, e.g., synaptic pruning, within the CNS that require a large amount of energy. Glucose appears to be the primary energy source, but microglia can utilize several other substrates for energy production including other sugars and ketone bodies. Recent studies have demonstrated that changes in the metabolic profiles of immune cells, including macrophages, are important in controlling their activation and effector functions. Additional studies have focused on the role of metabolism in neuron and astrocyte function while until recently microglia metabolism has been considerably less well understood. Considering many neurological disorders, such as neurodegeneration associated with AD, are associated with chronic inflammation and alterations in brain energy metabolism, it is hypothesized that microglial metabolism plays a significant role in the inflammatory responses of microglia during neurodegeneration. Here, we review the role of microglial immunometabolism in AD.
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影响因子：
64.5
作者：
Chang CH;Curtis JD;Maggi LB Jr;Faubert B;Villarino AV;O'Sullivan D;Huang SC;van der Windt GJ;Blagih J;Qiu J;Weber JD;Pearce EJ;Jones RG;Pearce EL
通讯作者：
Pearce EL
影响因子：
6.2
作者：
Deora, Vandana;Albornoz, Eduardo A.;Gordon, Richard
通讯作者：
Gordon, Richard
影响因子：
7.1
作者：
BACH, AC;BABAYAN, VK
通讯作者：
BABAYAN, VK
影响因子：
14
作者：
Fortier, Melanie;Castellano, Christian-Alexandre;Cunnane, Stephen C.
通讯作者：
Cunnane, Stephen C.
影响因子：
56.9
作者：
Alle, Henrik;Roth, Arnd;Geiger, Joerg R. P.
通讯作者：
Geiger, Joerg R. P.