Single-Strand Break End Resection in Genome Integrity: Mechanism and Regulation by APE2.
Single-Strand Break End Resection in Genome Integrity: Mechanism and Regulation by APE2.
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DOI：
10.3390/ijms19082389
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发表时间：
2018-08-14
影响因子：
5.6
通讯作者：
Yan S
中科院分区：
文献类型：
--
作者：
Hossain MA;Lin Y;Yan S
每个哺乳动物细胞每天发生DNA单链断裂（SSB）超过10，000次，是最常见的DNA损伤类型。未修复的SSB损害DNA复制和转录程序，导致基因组不稳定。未修复的SSB与癌症和神经退行性疾病等疾病有关。虽然经典的SSB修复途径被激活以修复大多数SSB，但仍不清楚未修复的SSB是否以及如何被感知和信号传导。在这篇综述中，我们提出了一个新的概念，SSB末端切除基因组的完整性。我们提出了SSB末端切除的四步机制：SSB末端感知和加工，以及SSB末端切除的启动、延续和终止。我们还比较了SSB末端切除和DSB末端切除在DNA修复和DNA损伤反应（DDR）途径中的不同机制。我们进一步讨论了SSB末端切除如何有助于SSB信号传导和修复。本文主要研究APE 2在SSB末端切除中的作用机制及其对基因组完整性的调控。最后，我们确定了未来的研究领域，可能有助于我们获得进一步的机制洞察SSB结束切除的过程。总体而言，这篇评论提供了第一个全面的角度SSB端切除基因组的完整性。
DNA single-strand breaks (SSBs) occur more than 10,000 times per mammalian cell each day, representing the most common type of DNA damage. Unrepaired SSBs compromise DNA replication and transcription programs, leading to genome instability. Unrepaired SSBs are associated with diseases such as cancer and neurodegenerative disorders. Although canonical SSB repair pathway is activated to repair most SSBs, it remains unclear whether and how unrepaired SSBs are sensed and signaled. In this review, we propose a new concept of SSB end resection for genome integrity. We propose a four-step mechanism of SSB end resection: SSB end sensing and processing, as well as initiation, continuation, and termination of SSB end resection. We also compare different mechanisms of SSB end resection and DSB end resection in DNA repair and DNA damage response (DDR) pathways. We further discuss how SSB end resection contributes to SSB signaling and repair. We focus on the mechanism and regulation by APE2 in SSB end resection in genome integrity. Finally, we identify areas of future study that may help us gain further mechanistic insight into the process of SSB end resection. Overall, this review provides the first comprehensive perspective on SSB end resection in genome integrity.
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影响因子：
4.8
作者：
Bai L;Michael WM;Yan S
通讯作者：
Yan S
DOI：
10.1186/s41021-017-0087-7
发表时间：
2017
期刊：
Genes and environment : the official journal of the Japanese Environmental Mutagen Society
影响因子：
--
作者：
Funakoshi M;Nambara D;Hayashi Y;Zhang-Akiyama QM
通讯作者：
Zhang-Akiyama QM
影响因子：
7.4
作者：
Abbotts R;Wilson DM 3rd
通讯作者：
Wilson DM 3rd
DOI：
10.1038/nrm.2017.53
发表时间：
2017-10
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
Ray Chaudhuri A;Nussenzweig A
通讯作者：
Nussenzweig A
影响因子：
16
作者：
Ciccia A;Elledge SJ
通讯作者：
Elledge SJ