The COVID-19 Self-Testing through Rapid Network Distribution (C-STRAND) trial: A randomized controlled trial to increase COVID-19 testing in underserved populations.
The COVID-19 Self-Testing through Rapid Network Distribution (C-STRAND) trial: A randomized controlled trial to increase COVID-19 testing in underserved populations.
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DOI：
10.1016/j.cct.2021.106585
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发表时间：
2021-11
影响因子：
2.2
通讯作者：
Gross R
中科院分区：
文献类型：
--
作者：
Bien-Gund CH;Shah J;Ho JI;Stephens-Shields A;Shea K;Fishman J;Thirumurthy H;Acri T;Dugosh K;Gross R
背景广泛开展人群检测对控制当前COVID-19大流行的公共卫生工作至关重要。然而，在受COVID-19影响严重的服务不足社区，COVID-19检测率一直很低。提高检测率的一种方法是通过二次分发自我收集试剂盒，即个人向其社会网络中的接触者分发检测试剂盒，并鼓励他们自我收集检测标本。我们概述了一项随机临床试验，通过快速网络分发（C-STRAND）进行COVID-19自我检测，以及一项COVID-19个体的队列研究，以确定二次分发策略对医疗服务不足人群中COVID-19检测的影响。方法该临床试验将从宾夕法尼亚州费城的联邦卫生合格中心招募1048名成人指数参与者，寻求COVID-19检测。符合条件的参与者将按1:1的比例随机分配，接受多个自我收集测试包或多次推荐进行标准的基于诊所的测试，以分发给其社交网络中的联系人。主要结果将是在8周时对至少两名网络接触者进行检测。COVID-19 C-STRAND检测呈阳性的指数参与者和网络接触者将有资格参加COVID-19密切接触者自检研究（nearest），评估在COVID-19患者中进行自我收集检测试剂盒的二次分发。该队列的主要结果将是在8周时检测呈阳性的密切接触者人数。结论有必要采取新策略促进COVID-19检测，特别是在受COVID-19影响最严重的服务不足人群中。我们将确定自我测试的二次分销策略的有效性。研究结果可为在当前大流行期间提高检测率提供参考。
Background Widely available population testing is critical to public health efforts to control the ongoing COVID-19 pandemic. However, COVID-19 testing has been low in underserved communities disproportionately affected by COVID-19. One approach to increase testing rates is through the secondary distribution of self-collection kits, where an individual distributes test kits to contacts in their social network and encourages them to self-collect test specimens. We outline a randomized clinical trial, COVID-19 Self-testing Through Rapid Network Distribution (C-STRAND), and a cohort study of individuals with COVID-19, to determine the impact of a secondary distribution strategy on COVID-19 testing among medically underserved populations. Methods The clinical trial will seek to enroll 1048 adult index participants from federally health qualified centers in Philadelphia, PA seeking COVID-19 testing. Eligible participants will be randomized 1:1 to receive multiple self-collection test kits or multiple referrals for standard clinic-based tests to distribute to contacts within their social network. The primary outcome will be testing among at least two network contacts at 8 weeks. Index participants and network contacts who test positive for COVID-19 from C-STRAND will be eligible to join the COVID-19 Close Contact Self-testing Study (CloseST), assessing the secondary distribution of self-collection test kits among individuals with COVID-19. The primary outcome of this cohort will be the number of close contacts who test positive at 8 weeks. Conclusion Novel strategies to promote COVID-19 testing are necessary, particularly among underserved populations most affected by COVID-19. We will determine the efficacy of a self-testing secondary distribution strategy. The results may inform efforts to increase testing rates during the current pandemic.
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影响因子：
11.1
作者：
Carethers, J. M.
通讯作者：
Carethers, J. M.
DOI：
10.1093/cid/ciaa1848
发表时间：
2021-11-02
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Mody A;Pfeifauf K;Bradley C;Fox B;Hlatshwayo MG;Ross W;Sanders-Thompson V;Joynt Maddox K;Reidhead M;Schootman M;Powderly WG;Geng EH
通讯作者：
Geng EH
DOI：
10.1007/s40615-020-00833-4
发表时间：
2020-09-01
影响因子：
3.9
作者：
Abedi, Vida;Olulana, Oluwaseyi;Zand, Ramin
通讯作者：
Zand, Ramin
影响因子：
5.5
作者：
Lieberman-Cribbin, Wil;Tuminello, Stephanie;Taioli, Emanuela
通讯作者：
Taioli, Emanuela
影响因子：
15.8
作者：
Golden, Matthew R.;Kerani, Roxanne P.;Holmes, King K.
通讯作者：
Holmes, King K.