Cerebrospinal fluid biomarkers in Parkinson's disease with freezing of gait: an exploratory analysis.
Cerebrospinal fluid biomarkers in Parkinson's disease with freezing of gait: an exploratory analysis.
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DOI：
10.1038/s41531-021-00247-x
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发表时间：
2021-11-29
期刊：
影响因子：
--
通讯作者：
Factor SA
中科院分区：
文献类型：
--
作者：
Hatcher-Martin JM;McKay JL;Pybus AF;Sommerfeld B;Howell JC;Goldstein FC;Wood L;Hu WT;Factor SA
我们探讨了帕金森病（PD）患者的三种阿尔茨海默病相关和十种炎症相关CSF标志物与步态冻结（FOG）之间的关系。研究人群包括伴有FOG的PD患者（PD-FOG，N = 12）、无FOG的PD患者（PD-NoFOG，N = 19）和健康对照（HC，N = 12）。年龄和PD持续时间在组间无显著差异。调整协变量和多重比较后，PD组的抗炎标志物fractalkine与HC组相比显著降低（P = 0.002），PD-FOG组与PD-NoFOG组相比进一步降低（P = 0.007）。与PD-NoFOG和HC相比，PD-FOG中阿尔茨海默病相关蛋白Aβ42增加（P = 0.001）。通过多元判别偏最小二乘回归证实了个体生物标志物分析中获得的组差异（P < 0.001）。PD-FOG患者中高水平的Aβ42支持从早期到晚期状态随时间增加。低水平的fractalkine可能提示抗炎作用。这些研究结果值得推广。
We explore the association between three Alzheimer’s disease-related and ten inflammation-related CSF markers and freezing of gait (FOG) in patients with Parkinson’s disease (PD). The study population includes PD patients with FOG (PD-FOG, N = 12), without FOG (PD-NoFOG, N = 19), and healthy controls (HC, N = 12). Age and PD duration are not significantly different between groups. After adjusting for covariates and multiple comparisons, the anti-inflammatory marker, fractalkine, is significantly decreased in the PD groups compared to HC (P = 0.002), and further decreased in PD-FOG compared to PD-NoFOG (P = 0.007). The Alzheimer’s disease-related protein, Aβ42, is increased in PD-FOG compared to PD-NoFOG and HC (P = 0.001). Group differences obtained in individual biomarker analyses are confirmed with multivariate discriminant partial least squares regression (P < 0.001). High levels of Aβ42 in PD-FOG patients supports an increase over time from early to advanced state. Low levels of fractalkine might suggest anti-inflammatory effect. These findings warrant replication.
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影响因子：
9.9
作者：
Hu, William T.;Watts, Kelly;Levey, Allan I.
通讯作者：
Levey, Allan I.
影响因子：
11
作者：
HUGHES, AJ;DANIEL, SE;LEES, AJ
通讯作者：
LEES, AJ
影响因子：
4.1
作者：
Factor, S. A.;Scullin, M. K.;Goldstein, F. C.
通讯作者：
Goldstein, F. C.
影响因子：
11.2
作者：
Irwin, David J.;Fedler, Janel;Shaw, Leslie M.
通讯作者：
Shaw, Leslie M.
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y