Integration of longitudinal and circumferential strain predicts volumetric change across the cardiac cycle and differentiates patients along the heart failure continuum.
Integration of longitudinal and circumferential strain predicts volumetric change across the cardiac cycle and differentiates patients along the heart failure continuum.
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DOI：
10.1186/s12968-023-00969-2
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发表时间：
2023-10-02
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影响因子：
--
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中科院分区：
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左心室（LV）周向和纵向应变提供了对LV力学和功能的重要见解，每个都有助于整个心动周期的体积变化。我们试图探索更详细的应变-体积关系，通过数学积分周向和纵向应变和应变率来预测LV体积和体积变化率。评价了来自阿尔伯塔心脏研究的229名参与者（46名健康对照，77名有发生心力衰竭[HF]风险的个体，70名诊断为射血分数保留的HF患者[HFpEF]和36名诊断为射血分数降低的HF患者[HFrEF]）的心脏磁共振（CMR）成像。通过圆盘法评估LV体积，并通过CMR特征跟踪评估应变/应变率。当与金标准容积评估（EF体积：r = 0.94，P < 0.0001）相比时，整合心内膜周向和纵向应变提供了LV射血分数（EF应变）的近似值。同样地，整合周向和纵向应变率提供了峰值射血和峰值充盈率（分别为PER应变和PFRStrain）与其金标准容积-时间等效值（分别为PER体积，r = 0.73，P < 0.0001和PFRVolume，r = 0.78，P < 0.0001）的密切近似。此外，每个综合应变测量区分了HF连续体中的患者（所有P < 0.01），与所有其他组相比，HFrEF组具有更差的EF应变、PER应变和PFRStrain，与风险组和对照组相比，HFpEF具有更差的EF应变和PFRStrain。本文的数据建立了将离散应变分量整合到心动周期的体积测量中的理论框架，并突出了这种方法用于区分沿着心力衰竭连续体的患者的潜在益处。
Left ventricular (LV) circumferential and longitudinal strain provide important insight into LV mechanics and function, each contributing to volumetric changes throughout the cardiac cycle. We sought to explore this strain-volume relationship in more detail, by mathematically integrating circumferential and longitudinal strain and strain rate to predict LV volume and volumetric rates of change. Cardiac magnetic resonance (CMR) imaging from 229 participants from the Alberta HEART Study (46 healthy controls, 77 individuals at risk for developing heart failure [HF], 70 patients with diagnosed HF with preserved ejection fraction [HFpEF], and 36 patients with diagnosed HF with reduced ejection fraction [HFrEF]) were evaluated. LV volume was assessed by the method of disks and strain/strain rate were assessed by CMR feature tracking. Integrating endocardial circumferential and longitudinal strain provided a close approximation of LV ejection fraction (EFStrain), when compared to gold-standard volumetric assessment (EFVolume: r = 0.94, P < 0.0001). Likewise, integrating circumferential and longitudinal strain rate provided a close approximation of peak ejection and peak filling rates (PERStrain and PFRStrain, respectively) compared to their gold-standard volume-time equivalents (PERVolume, r = 0.73, P < 0.0001 and PFRVolume, r = 0.78, P < 0.0001, respectively). Moreover, each integrated strain measure differentiated patients across the HF continuum (all P < 0.01), with the HFrEF group having worse EFStrain, PERStrain, and PFRStrain compared to all other groups, and HFpEF having less favorable EFStrain and PFRStrain compared to both at-risk and control groups. The data herein establish the theoretical framework for integrating discrete strain components into volumetric measurements across the cardiac cycle, and highlight the potential benefit of this approach for differentiating patients along the heart failure continuum.
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DOI：
10.1016/j.amjcard.2017.11.033
发表时间：
2018-03-01
期刊：
The American journal of cardiology
影响因子：
--
作者：
Hieda M;Parker J;Rajabi T;Fujimoto N;Bhella PS;Prasad A;Hastings JL;Sarma S;Levine BD
通讯作者：
Levine BD
影响因子：
7.5
作者：
Kuznetsova, Tatiana;Cauwenberghs, Nicholas;Staessen, Jan A.
通讯作者：
Staessen, Jan A.
心脏磁共振容量-时间曲线评估2型糖尿病冠心病患者左心室功能障碍
影响因子：
2.1
作者：
Xu, Hua-yan;Yang, Zhi-gang;Xie, Lin-jun
通讯作者：
Xie, Lin-jun
影响因子：
24
作者：
Stokke, Thomas M.;Hasselberg, Nina E.;Remme, Espen W.
通讯作者：
Remme, Espen W.
影响因子：
14
作者：
Sengupta, Partho P.;Tajik, A. Jamil;Khandheria, Bijoy K.
通讯作者：
Khandheria, Bijoy K.