Associations between TCF7L2 polymorphisms and risk of breast cancer among Hispanic and non-Hispanic white women: the Breast Cancer Health Disparities Study.
Associations between TCF7L2 polymorphisms and risk of breast cancer among Hispanic and non-Hispanic white women: the Breast Cancer Health Disparities Study.
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DOI：
10.1007/s10549-012-2299-7
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发表时间：
2012-11
影响因子：
3.8
通讯作者：
Slattery, Martha L.
中科院分区：
文献类型：
--
作者：
Connor, Avonne E.;Baumgartner, Richard N.;Baumgartner, Kathy B.;Kerber, Richard A.;Pinkston, Christina;John, Esther M.;Torres-Mejia, Gabriela;Hines, Lisa;Giuliano, Anna;Wolff, Roger K.;Slattery, Martha L.
转录因子7样2（TCF 7 L2）基因是Wnt/β-catenin信号通路的一部分，在细胞发育和生长调节中起关键作用。TCF 7 L2变体rs 12255372和rs7903146与2型糖尿病风险相关。很少有流行病学研究探讨了TCF 7 L2与乳腺癌风险之间的关系。我们调查了来自四角乳腺癌研究、旧金山弗朗西斯科湾区乳腺癌研究和墨西哥乳腺癌研究的西班牙裔和非西班牙裔白色（NHW）女性中25个TCF 7 L2单核苷酸多态性（SNP）与乳腺癌之间的关联。共有4，703名西班牙裔（2，093例，2，610名对照）和3，031名NHW（1，431例，1，600名对照）女性被纳入。使用逻辑回归计算比值比（OR）和95%置信区间（CI），以估计TCF 7 L2 SNP与乳腺癌风险之间的关联。我们还研究了自我报告的种族，遗传混杂和糖尿病史的影响修改。调整多重比较后，四个TCF 7 L2 SNP与乳腺癌总体显著相关：rs7903146（ORTT 1.24; 95% CI 1.03-1.49），rs3750805（ORAT/TT 1.15; 95% CI 1.03-1.28）、rs7900150（ORAA 1.23; 95% CI 1.07-1.42）和rs1225404（ORCC 0.82; 95% CI 0.70-0.94）。在有糖尿病史的女性中，rs3750804的TT基因型增加了乳腺癌的风险（OR，2.46; 95%CI 1.28-4.73）。然而，在无糖尿病史的女性中没有相关性（OR，1.06; 95%CI 0.85-1.32）。我们没有发现种族或遗传混合物的显着相互作用。研究结果支持TCF 7 L2与乳腺癌之间的关联，糖尿病史改变了特定变体的这种关联。
The transcription factor 7-like 2 (TCF7L2) gene is part of the Wnt/β-catenin signaling pathway and plays a critical role in cell development and growth regulation. TCF7L2 variants rs12255372 and rs7903146 have been associated with risk of Type 2 diabetes. Few epidemiological studies have examined the association between TCF7L2 and breast cancer risk. We investigated the associations between 25 TCF7L2 single nucleotide polymorphisms (SNPs) and breast cancer in Hispanic and non-Hispanic white (NHW) women from the 4-Corner’s Breast Cancer Study, the San Francisco Bay Area Breast Cancer Study, and the Mexico Breast Cancer Study. A total of 4,703 Hispanic (2,093 cases, 2,610 controls) and 3,031 NHW (1,431 cases, 1,600 controls) women were included. Odds ratios (OR) and 95 % confidence intervals (CI) were calculated using logistic regression to estimate the association between the TCF7L2 SNPs and breast cancer risk. We also examined effect modification by self-reported ethnicity, genetic admixture, and diabetes history. After adjusting for multiple comparisons, four TCF7L2 SNPs were significantly associated with breast cancer overall: rs7903146 (ORTT 1.24; 95 % CI 1.03–1.49), rs3750805 (ORAT/TT 1.15; 95 % CI 1.03–1.28), rs7900150 (ORAA 1.23; 95 % 1.07–1.42), and rs1225404 (ORCC 0.82; 95 % 0.70–0.94). Among women with a history of diabetes, the TT genotype of rs3750804 increased breast cancer risk (OR, 2.46; 95 % CI 1.28–4.73). However, there was no association among women without a diabetes history (OR, 1.06; 95 % CI 0.85–1.32). We did not find significant interactions by ethnicity or by genetic admixture. Findings support an association between TCF7L2 and breast cancer and history of diabetes modifies this association for specific variants.
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影响因子：
16.2
作者：
Michels, KB;Solomon, CG;Manson, JE
通讯作者：
Manson, JE
影响因子：
6.2
作者：
Chung, GG;Zerkowski, MP;Rimm, DL
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3.8
作者：
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通讯作者：
Ji, L
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作者：
Bodhini, Dhanasekaran;Radha, Venkatesan;Mohan, Viswanathan
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Mohan, Viswanathan
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7.5
作者：
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