GABA and central neuropathic pain following spinal cord injury.
GABA and central neuropathic pain following spinal cord injury.
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DOI：
10.1016/j.neuropharm.2010.12.030
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发表时间：
2011-04
影响因子：
4.7
通讯作者：
Hulsebosch, Claire E.
中科院分区：
文献类型：
--
作者：
Gwak, Young S.;Hulsebosch, Claire E.
脊髓损伤引起体感觉系统突触传递不良，导致慢性中枢神经性疼痛。最近的文献表明，神经胶质-神经元相互作用是脊髓损伤后突触传递的重要调节因子。神经高兴奋性是脊髓损伤后神经胶质-神经元相互作用改变导致突触传递不适应的主要现象之一。在体感觉系统中，脊髓抑制性神经元对抗外周输入增强的突触传递。近十年来，文献表明gaba能抑制性张力的功能减退是脊髓损伤后突触传递增强的一个重要因素，突触传递往往导致背角神经元的神经兴奋性亢进。神经元和神经胶质细胞通过调节氯离子转运体、细胞外谷氨酸和GABA浓度，通过摄取机制协同控制细胞内氯离子梯度。因此，维持细胞内“gaba -谷氨酸-谷氨酰胺循环”以维持正常的生理稳态。然而，脊髓损伤后过度兴奋的神经元和神经胶质激活破坏了氯离子、谷氨酸和GABA在脊髓背角的分布平衡，导致慢性神经性疼痛。在这篇综述中，我们探讨了脊髓损伤诱导的gaba能张力功能低下导致慢性中枢神经性疼痛的机制。
Spinal cord injury induces maladaptive synaptic transmission in the somatosensory system that results in chronic central neuropathic pain. Recent literature suggests that glial-neuronal interactions are important modulators in synaptic transmission following spinal cord injury. Neuronal hyperexcitability is one of the predominant phenomenon caused by maladaptive synaptic transmission via altered glial-neuronal interactions after spinal cord injury. In the somatosensory system, spinal inhibitory neurons counter balance the enhanced synaptic transmission from peripheral input. For a decade, the literature suggests that hypofunction of GABAergic inhibitory tone is an important factor in the enhanced synaptic transmission that often results in neuronal hyperexcitability in dorsal horn neurons following spinal cord injury. Neurons and glial cells synergistically control intracellular chloride ion gradients via modulation of chloride transporters, extracellular glutamate and GABA concentrations via uptake mechanisms. Thus, the intracellular “GABA-glutamate-glutamine cycle” is maintained for normal physiological homeostasis. However, hyperexcitable neurons and glial activation after spinal cord injury disrupts the balance of chloride ions, glutamate and GABA distribution in the spinal dorsal horn and results in chronic neuropathic pain. In this review, we address spinal cord injury induced mechanisms in hypofunction of GABAergic tone that results in chronic central neuropathic pain.
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影响因子：
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作者：
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发表时间：
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影响因子：
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