Vascular Endothelial Growth Factor remains unchanged in cerebrospinal fluid of patients with Alzheimer's disease and vascular dementia.
Vascular Endothelial Growth Factor remains unchanged in cerebrospinal fluid of patients with Alzheimer's disease and vascular dementia.
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DOI：
10.1186/s13195-018-0385-8
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发表时间：
2018-06-23
期刊：
影响因子：
--
通讯作者：
de Vries HE
中科院分区：
文献类型：
--
作者：
Chakraborty A;Chatterjee M;Twaalfhoven H;Del Campo Milan M;Teunissen CE;Scheltens P;Fontijn RD;van Der Flier WM;de Vries HE
越来越多的证据表明，脑血管功能障碍与阿尔茨海默病（AD）的早期阶段有关。血管内皮生长因子（VEGF）是参与血管系统发育和维持的关键因素之一。在这里，我们假设，脑脊髓液（CSF）中的VEGF水平可能会改变AD患者的血管受累，其特征是存在微出血（MB），并在血管性痴呆（VaD）患者与对照组相比。通过电化学发光Meso Scale Discovery（MULTI-SPOT Assay System）测定来自年龄匹配组的CSF中的VEGF水平，所述年龄匹配组为具有主观认知下降的对照组（n = 21）、无MB的AD（n = 25）、具有MB的AD（n = 25）和VaD（n = 21）患者。各组CSF中VEGF的平均水平为2.8 ± 1 pg/ml。校正年龄和性别后，未检测到组间显著差异（p > 0.5）。然而，我们检测到CSF中VEGF浓度与年龄之间的显著相关性（r = 0.22，p = 0.03）。此外，男性（n = 54）的CSF中VEGF水平高于女性（n = 38）（男性= 3.08 ± 0.769 pg/ml（平均值± SD），女性= 2.6 ± 0.59; p = 0.006），表明存在性别相关调节。我们的研究表明，在CSF中的VEGF水平并不反映在AD或VaD患者的脑血管病变。观察到的VEGF与年龄和性别的关系可能表明VEGF反映了正常的衰老，男性和女性的衰老过程可能不同。本文的在线版本（10.1186/s13195-018-0385-8）包含补充材料，可供授权用户使用。
Increasing evidence suggests that cerebral vascular dysfunction is associated with the early stages of Alzheimer’s disease (AD). Vascular endothelial growth factor (VEGF) is one of the key players involved in the development and maintenance of the vasculature. Here, we hypothesized that VEGF levels in cerebrospinal fluid (CSF) may be altered in AD patients with vascular involvement, characterized by the presence of microbleeds (MB), and in vascular dementia (VaD) patients compared to controls. VEGF levels were determined by electrochemilumiscence Meso Scale Discovery (MULTI-SPOT Assay System) in CSF from age-matched groups of controls with subjective cognitive decline (n = 21), AD without MB (n = 25), AD with MB (n = 25), and VaD (n = 21) patients. The average level of VEGF in the different groups was 2.8 ± 1 pg/ml CSF. Adjusted for age and gender, no significant differences were detected between groups (p > 0.5). However, we detected a significant correlation between the concentration of VEGF in the CSF and age (r = 0.22, p = 0.03). In addition, males (n = 54) revealed higher VEGF levels in their CSF compared to females (n = 38) (males = 3.08 ± 0.769 pg/ml (mean ± SD), females = 2.6 ± 0.59; p = 0.006), indicating a gender-related regulation. Our study suggests that VEGF levels in the CSF do not reflect the cerebral vascular alterations in either AD or VaD patients. The observed associations of VEGF with age and gender may indicate that VEGF reflects normal aging and that males and females may differ in their aging process. The online version of this article (10.1186/s13195-018-0385-8) contains supplementary material, which is available to authorized users.
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血管内皮生长因子在神经退行性和认知下降中的作用：探索与阿尔茨海默氏病的生物标志物的相互作用。
影响因子：
29
作者：
Hohman, Timothy J.;Bell, Susan P.;Jefferson, Angela L.
通讯作者：
Jefferson, Angela L.
影响因子：
2.4
作者：
Blasko, I;Lederer, W;Humpel, C
通讯作者：
Humpel, C
DOI：
10.1186/s13195-017-0271-9
发表时间：
2017-07-03
期刊：
Alzheimer's research & therapy
影响因子：
--
作者：
Li G;Shofer JB;Petrie EC;Yu CE;Wilkinson CW;Figlewicz DP;Shutes-David A;Zhang J;Montine TJ;Raskind MA;Quinn JF;Galasko DR;Peskind ER
通讯作者：
Peskind ER
影响因子：
2.6
作者：
Knopman, D. S.
通讯作者：
Knopman, D. S.
DOI：
10.1016/j.jalz.2013.10.005
发表时间：
2015-03
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Chêne G;Beiser A;Au R;Preis SR;Wolf PA;Dufouil C;Seshadri S
通讯作者：
Seshadri S