Dose and age-dependent axonal responses of embryonic trigeminal neurons to localized NGF via p75NTR receptor.
Dose and age-dependent axonal responses of embryonic trigeminal neurons to localized NGF via p75NTR receptor.
复制标题
胚胎三叉神经元通过 p75NTR 受体对局部 NGF 的剂量和年龄依赖性轴突反应。
DOI：
10.1002/neu.20074
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Erzurumlu,RehaS
中科院分区：
文献类型：
--
作者：
Ozdinler,PHande;Ulupinar,Emel;Erzurumlu,RehaS
神经生长因子（NGF）和相关神经营养因子是感觉神经元的靶源生存因子。此外，这些肽调节神经元分化、轴突引导和突触可塑性。我们在胶原凝胶分析中测试了胚胎三叉神经元轴突对NGF局部来源的行为。在发育的早期阶段，三叉神经轴突优先向低剂量的局部NGF生长，并远离高浓度的NGF生长，但在后期不表现出这种反应。背根神经节轴突对NGF也表现出类似的反应，但依赖NGF的颈上神经节轴突则没有。在bax - / -小鼠中也观察到这种轴突对局部NGF源的反应，这表明轴突效应在很大程度上与细胞存活无关。免疫细胞化学研究表明，向或远离局部NGF生长的轴突TrkA‐阳性，TrkA−/−TG轴突对任何剂量的NGF均无反应。我们进一步表明，在缺乏p75神经营养因子受体（p75NTR）的小鼠中提取的TG中，轴突对NGF的反应缺失。总的来说，我们的研究结果表明，局部来源的NGF可以通过表达TrkA的轴突介导p75ntr信号，以剂量和年龄依赖的方式指导三叉神经节轴突的生长。©2004 Wiley期刊公司神经生物学杂志，2005
Nerve growth factor (NGF) and related neurotrophins are target‐derived survival factors for sensory neurons. In addition, these peptides modulate neuronal differentiation, axon guidance, and synaptic plasticity. We tested axonal behavior of embryonic trigeminal neurons towards localized sources of NGF in collagen gel assays. Trigeminal axons preferentially grow towards lower doses of localized NGF and grow away from higher concentrations at earlier stages of development, but do not show this response later. Dorsal root ganglion axons also show similar responses to NGF, but NGF‐dependent superior cervical ganglion axons do not. Such axonal responses to localized NGF sources were also observed inBax−/−mice, suggesting that the axonal effects are largely independent of cell survival. Immunocytochemical studies indicated that axons, which grow towards or away from localized NGF are TrkA‐positive, andTrkA−/−TG axons do not respond to any dose of NGF. We further show that axonal responses to NGF are absent in TG derived from mice that lack the p75 neurotrophin receptor (p75NTR). Collectively, our results suggest that localized sources of NGF can direct axon outgrowth from trigeminal ganglion in a dose‐ and age‐dependent fashion, mediated by p75NTRsignaling through TrkA expressing axons. © 2004 Wiley Periodicals, Inc. J Neurobiol, 2005
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影响因子：
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DOI：
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发表时间：
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期刊：
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影响因子：
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