Smooth muscle signalling pathways in health and disease.
Smooth muscle signalling pathways in health and disease.
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DOI：
10.1111/j.1582-4934.2008.00552.x
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发表时间：
2008-12
影响因子：
5.3
通讯作者：
Morgan KG
中科院分区：
文献类型：
--
作者：
Kim HR;Appel S;Vetterkind S;Gangopadhyay SS;Morgan KG
Smooth muscle contractile activity is a major regulator of function of the vascular system, respiratory system, gastrointestinal system and the genitourinary systems. Malfunction of contractility in these systems leads to a host of clinical disorders, and yet, we still have major gaps in our understanding of the molecular mechanisms by which contractility of the differentiated smooth muscle cell is regulated. This review will summarize recent advances in the molecular understanding of the regulation of smooth muscle myosin activity via phosphorylation/dephosphorylation of myosin, the regulation of the accessibility of actin to myosin via the actin-binding proteins calponin and caldesmon, and the remodelling of the actin cytoskeleton. Understanding of the molecular ‘players’ should identify target molecules that could point the way to novel drug discovery programs for the treatment of smooth muscle disorders such as cardiovascular disease, asthma, functional bowel disease and pre-term labour.
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影响因子：
56.9
作者：
De Koninck, P;Schulman, H
通讯作者：
Schulman, H
影响因子：
2.1
作者：
Ali, F;Paré, PD;Seow, CY
通讯作者：
Seow, CY
影响因子：
5.3
作者：
Crawford, K;Flick, R;Lessard, J
通讯作者：
Lessard, J
影响因子：
--
作者：
DREW, JS;MOOS, C;MURPHY, RA
通讯作者：
MURPHY, RA
影响因子：
4.8
作者：
Deng, JT;Van Lierop, JE;Walsh, MP
通讯作者：
Walsh, MP