The multifaceted functions of cGAS.
The multifaceted functions of cGAS.
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cGAS的多方面功能
DOI：
10.1093/jmcb/mjac031
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发表时间：
2022-09-15
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
Pattern recognition receptors are critical for the sensing of pathogen-associated molecular patterns or danger-associated molecular patterns and subsequent mounting of innate immunity and shaping of adaptive immunity. The identification of 2′3′-cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) synthase (cGAS) as a major cytosolic DNA receptor is a milestone in the field of DNA sensing. The engagement of cGAS by double-stranded DNA from different origins, including invading pathogens, damaged mitochondria, ruptured micronuclei, and genomic DNA results in the generation of cGAMP and activation of stimulator of interferon genes, which thereby activates innate immunity mainly characterized by the activation of type I interferon response. In recent years, great progress has been made in understanding the subcellular localization and novel functions of cGAS. In this review, we particularly focus on summarizing the multifaceted roles of cGAS in regulating senescence, autophagy, cell stemness, apoptosis, angiogenesis, cell proliferation, antitumor effect, DNA replication, DNA damage repair, micronucleophagy, as well as cell metabolism.
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影响因子：
64.8
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影响因子：
32.4
作者：
Gall A;Treuting P;Elkon KB;Loo YM;Gale M Jr;Barber GN;Stetson DB
通讯作者：
Stetson DB
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通讯作者：
Elkon, Keith B.
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64.5
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通讯作者：
Kagan, Jonathan C.
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4.8
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Chen, Min;Yao, Lijie;Peng, Hongjuan
通讯作者：
Peng, Hongjuan