Clinical review of cerebral venous thrombosis in the context of COVID-19 vaccinations: Evaluation, management, and scientific questions.

Clinical review of cerebral venous thrombosis in the context of COVID-19 vaccinations: Evaluation, management, and scientific questions.
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DOI:
10.1016/j.jns.2021.117532
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发表时间:
2021-08-15
影响因子:
4.4
通讯作者:
Elkind MS
Elkind MS
中科院分区:
医学3区
文献类型:
--
作者:
Thakur KT;Tamborska A;Wood GK;McNeill E;Roh D;Akpan IJ;Miller EC;Bautista A;Claassen J;Kim CY;Guekht A;Pardo CA;Williams O;García-Azorín D;Prasad K;Schmutzhard E;Michael BD;Chou SH;Winkler AS;Solomon T;Elkind MS

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疫苗诱导的免疫介导的血小板减少症(VITT)是最近发生的一种罕见的血小板减少症血栓形成现象,通常包括脑静脉血栓形成(CVT),在接种腺病毒疫苗ChAdOx1 nCOV-19(阿斯利康)和Ad26后发生。COV2·强生公司(Janssen/J&J)。评估和管理COVID-19疫苗接种后CVT疑似病例是广泛的卫生保健提供者的关键技能。在全球神经学家和血液学家的专家小组中进行了文献的协作综合审查。在可能发生VITT的情况下,快速评估和治疗CVT的策略包括炎症标志物测量、PF4检测和非肝素抗凝。
Vaccine induced immune mediated thrombocytopenia or VITT, is a recent and rare phenomenon of thrombosis with thrombocytopenia, frequently including cerebral venous thromboses (CVT), that has been described following vaccination with adenovirus vaccines ChAdOx1 nCOV-19 (AstraZeneca) and Ad26.COV2·S Johnson and Johnson (Janssen/J&J). The evaluation and management of suspected cases of CVT post COVID-19 vaccination are critical skills for a broad range of healthcare providers. A collaborative comprehensive review of literature was conducted among a global group of expert neurologists and hematologists. Strategies for rapid evaluation and treatment of the CVT in the context of possible VITT exist, including inflammatory marker measurements, PF4 assays, and non-heparin anticoagulation.
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