Functional heterogeneity and adaptation of naive T cells in response to tonic TCR signals.
Functional heterogeneity and adaptation of naive T cells in response to tonic TCR signals.
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DOI：
10.1016/j.coi.2021.09.007
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发表时间：
2021-12
影响因子：
7
通讯作者：
Au-Yeung BB
中科院分区：
文献类型：
--
作者：
Eggert J;Au-Yeung BB
成熟的CD4+和CD8+ T细胞响应于自身抗原而组成性地经历弱T细胞受体（TCR）刺激，称为强直（或基础）信号传导。紧张性TCR信号强度如何影响T细胞对外来抗原的应答是一个活跃的研究领域。这些研究依赖于紧张性信号强度的替代标记物，包括CD5、Ly6C和Nr4a基因的转基因报告基因。最近的研究表明，强的紧张性TCR信号强度影响基础T细胞代谢，效应分化和TCR信号转导。经历最强的紧张性TCR信号传导的T细胞表现出T细胞活化和负调节的特征。这些数据表明了一种模型，其中对紧张性信号的适应具有改变T细胞活化和分化的持久影响。
Mature CD4+ and CD8+ T cells constitutively experience weak T cell receptor (TCR) stimulation in response to self-antigens, termed tonic (or basal) signaling. How tonic TCR signal strength impacts T cell responses to foreign antigens is an active area of investigation. Such studies rely on surrogate markers of tonic signal strength, including CD5, Ly6C, and transgenic reporters of Nr4a genes. Recent research indicates that strong tonic TCR signal strength influences basal T cell metabolism, effector differentiation, and TCR signal transduction. T cells that experience the strongest tonic TCR signaling exhibit features of T cell activation and negative regulation. These data suggest a model whereby adaptation to tonic signaling has lasting effects that alter T cell activation and differentiation.
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影响因子：
30.5
作者：
Bartleson JM;Viehmann Milam AA;Donermeyer DL;Horvath S;Xia Y;Egawa T;Allen PM
通讯作者：
Allen PM
影响因子：
82.9
作者：
Long, Adrienne H.;Haso, Waleed M.;Shern, Jack F.;Wanhainen, Kelsey M.;Murgai, Meera;Ingaramo, Maria;Smith, Jillian P.;Walker, Alec J.;Kohler, M. Eric;Venkateshwara, Vikas R.;Kaplan, Rosandra N.;Patterson, George H.;Fry, Terry J.;Orentas, Rimas J.;Mackall, Crystal L.
通讯作者：
Mackall, Crystal L.
影响因子：
30.5
作者：
通讯作者：
--
DOI：
10.1073/pnas.1413726111
发表时间：
2014-09-02
影响因子：
11.1
作者：
Au-Yeung, Byron B.;Zikherman, Julie;Weiss, Arthur
通讯作者：
Weiss, Arthur
影响因子：
8.8
作者：
Jennings E;Elliot TAE;Thawait N;Kanabar S;Yam-Puc JC;Ono M;Toellner KM;Wraith DC;Anderson G;Bending D
通讯作者：
Bending D