Ovarian Clear Cell Carcinoma Sub-Typing by ARID1A Expression.
Ovarian Clear Cell Carcinoma Sub-Typing by ARID1A Expression.
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DOI：
10.3349/ymj.2017.58.1.59
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发表时间：
2017-01
影响因子：
2.4
通讯作者：
Cho NH
中科院分区：
文献类型：
--
作者：
Choi JY;Han HH;Kim YT;Lee JH;Kim BG;Kang S;Cho NH
卵巢透明细胞癌(O-CCC)是一种介于浆液性和子宫内膜样亚型之间的三阴性卵巢癌，其分子和临床行为被认为是AT丰富的DNA相互作用结构域的缺失(ARID1A)。然而，大约一半的O-CCCs仍然表达ARID1A编码的蛋白质BAF250a。在这里，我们的目的是识别ARID1A阳性的O-CCC的特征，并与其阴性的特征进行比较。本研究共收集O-CCC患者70例。分析原发肿瘤的组织学分级和类型、分子标志物免疫组织化学图谱和临床结果。48例(69%)O-CCCs不表达BAF250a，标记为“ARID1A阴性”。其他22例(31%)O-CCC被指定为“ARID1A阳性”。与ARID1a阴性的肿瘤相比，ARID1a阳性的肿瘤在组织学上更有可能是高级别(41%比10%，p=0.003)，ERβ阳性(45%比17%，p=0.011)，而HNF1β阳性(77%比96%，p=0.016)和E-钙粘素阳性(59%比83%，p=0.028)。两组患者年龄、产次、肿瘤分期差异无统计学意义。癌症特异性存活率也没有显著差异。我们根据ARID1A的表达状态对O-CCCS进行分类。ARID1A阳性的O-CCCS表现出与ARID1A阴性肿瘤不同的免疫组织化学特征，提示在癌变过程中发生了不同的潜在分子事件。
Loss of AT-rich DNA-interacting domain 1A (ARID1A) has been identified as a driving mutation of ovarian clear cell carcinoma (O-CCC), a triple-negative ovarian cancer that is intermediary between serous and endometrioid subtypes, in regards to molecular and clinical behaviors. However, about half of O-CCCs still express BAF250a, the protein encoded by ARID1A. Herein, we aimed to identify signatures of ARID1A-positive O-CCC in comparison with its ARID1A-negative counterpart. Seventy cases of O-CCC were included in this study. Histologic grades and patterns of primary tumor, molecular marker immunohistochemistry profiles, and clinical outcomes were analyzed. Forty-eight (69%) O-CCCs did not express BAF250a, which were designated as "ARID1A-negative." The other 22 (31%) O-CCCs were designated as "ARID1A-positive." ARID1A-positive tumors were more likely to be histologically of high grades (41% vs. 10%, p=0.003), ERβ-positive (45% vs. 17%, p=0.011), and less likely to be HNF1β-positive (77% vs. 96%, p=0.016) and E-cadherin-positive (59% vs. 83%, p=0.028) than ARID1A-negative tumors. Patient age, parity, tumor stage were not significantly different in between the two groups. Cancer-specific survival was not significantly different either. We classified O-CCCs according to ARID1A expression status. ARID1A-positive O-CCCs exhibited distinct immunohistochemical features from ARID1A-negative tumors, suggesting a different underlying molecular event during carcinogenesis.
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