The complexities of epidemiology and prevention of gastrointestinal cancers.
The complexities of epidemiology and prevention of gastrointestinal cancers.
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流行病学和预防胃肠癌的复杂性。
DOI：
10.3390/ijms131012556
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发表时间：
2012-10-01
影响因子：
5.6
通讯作者：
Sarkar FH
中科院分区：
文献类型：
--
作者：
Haq S;Ali S;Mohammad R;Sarkar FH
癌症流行病学和预防是当今研究最深入的领域之一。我们对这种疾病的发病率和发病机制了解得越多，我们就能更好地预防它。有效的预防策略可以显着降低癌症的死亡率；这就是为什么描述根本原因很重要。人们普遍认识到，散发性或遗传性的基因突变可能会导致肿瘤发生的机会增加。检测基因突变可以识别患有遗传性癌症综合征的高危个体，这可能有助于制定预防策略。此外，众所周知，环境因素在流行病学中发挥着重要作用，并提出了可用于降低癌症发病率以及随后的癌症相关发病率和死亡率的预防工具。化学预防已在结肠癌中进行了尝试，并且在其他癌症中也取得了新的进展。在许多环境癌症预防剂中，最引人注目的进展是维生素 E、维生素 D 和叶酸的作用的确定。研究表明，这些维生素的摄入量增加与癌症风险呈负相关。本综述将重点介绍胃肠道系统最具侵袭性癌症的癌症流行病学的重要方面，重点关注结直肠腺癌和胰腺腺癌。此外，还将回顾结直肠癌和胰腺癌流行病学的一些众所周知的和不断发展的方面以及当前和新的预防策略。
Cancer epidemiology and prevention is one of the most well studied fields today. The more we can understand about the incidence and pathogenesis of this disease, the better we will be able to prevent it. Effective prevention strategies can decrease the mortality rate of cancer significantly; this is why it is important to delineate the underlying causes. It has been well recognized that genetic mutations, sporadic or hereditary, may lead to increased chance of tumorigenesis. Detecting genetic mutations can lead to the identification of high-risk individuals with hereditary cancer syndromes, which may assist in devising prevention strategies. Further, environmental factors are known to play important roles in epidemiology and suggest prevention tools that could be implemented to reduce cancer incidence and subsequent cancer-associated morbidity and mortality. Chemoprevention has been tried in colon cancer and is finding new advancements in other carcinomas as well. Out of many environmental cancer preventive agents, the most notable developments are the identification of the role of vitamins E, vitamin D and folic acid. Increased consumption of these vitamins has shown to be inversely correlated with cancer risk. This review will highlight important aspects of cancer epidemiology in the most aggressive carcinomas of the gastrointestinal system focusing on colorectal adenocarcinoma and pancreatic adenocarcinoma. Additionally, some of the well-known and evolving aspects of epidemiology of colorectal and pancreatic cancer along with current and new prevention strategies will also be reviewed.
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影响因子：
2.2
作者：
Bulathsinghala P;Syrigos KN;Saif MW
通讯作者：
Saif MW
癌症中的线粒体：在生与死的十字路口。
影响因子：
--
作者：
Fogg VC;Lanning NJ;Mackeigan JP
通讯作者：
Mackeigan JP
影响因子：
6.2
作者：
Gadgeel, Shirish M.;Ali, Shadan;Sarkar, Fazlul H.
通讯作者：
Sarkar, Fazlul H.
影响因子：
4
作者：
Bao, Bin;Wang, Zhiwei;Ali, Shadan;Kong, Dejuan;Banerjee, Sanjeev;Ahmad, Aamir;Li, Yiwei;Azmi, Asfar S.;Miele, Lucio;Sarkar, Fazlul H.
通讯作者：
Sarkar, Fazlul H.
影响因子：
7.4
作者：
Chen, Long;Xu, Baoshan;Liu, Lei;Luo, Van;Zhou, Hongyu;Chen, Wenxing;Shen, Tao;Han, Xiuzhen;Kontos, Christopher D.;Huang, Shile
通讯作者：
Huang, Shile