Autophagy genes as tumor suppressors.
Autophagy genes as tumor suppressors.
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DOI：
10.1016/j.ceb.2009.11.003
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发表时间：
2010-04
影响因子：
7.5
通讯作者：
Jung JU
中科院分区：
文献类型：
--
作者：
Liang C;Jung JU
自噬最初被描述为一种普遍的溶酶体依赖的细胞质成分在营养缺乏时的大量降解，后来被证明影响体内平衡的各个方面，并与包括癌症在内的多种病理条件有关。随着自噬相关(ATG)基因的不断发现，与人类癌症的发生和发展以及对癌症治疗的反应相关的基因清单也在不断增加。然而，ATG基因是否通过其预期的自噬调节机制和/或通过尚不明确的功能在癌症的发展中发挥作用仍有待进一步阐明。在这里，我们综述了自噬基因的分子基础及其在肿瘤发展过程中的生物学输出方面的最新进展。更好地了解细胞自噬和肿瘤生长控制之间的机制联系，最终可能会更好地治疗人类癌症。
Autophagy, originally described as a universal lysosome-dependent bulk degradation of cytoplasmic components upon nutrient deprivation, has since been shown to influence diverse aspects of homeostasis and is implicated in a wide variety of pathological conditions, including cancer. The list of autophagy-related (Atg) genes associated with the initiation and progression of human cancer as well as with responses to cancer therapy continues to grow as these genes are being discovered. However, whether Atg genes work through their expected mechanisms of autophagy regulation and/or through as-yet-undefined functions in the development of cancer remains to be further clarified. Here we review recent advances in the knowledge of the molecular basis of autophagy genes and their biological outputs during tumor development. A better understanding of the mechanistic link between cellular autophagy and tumor growth control may ultimately better human cancer treatments.
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