The adipose-derived stem cell: looking back and looking ahead.

The adipose-derived stem cell: looking back and looking ahead.
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DOI:
10.1091/mbc.e09-07-0589
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发表时间:
2010-06-01
影响因子:
3.3
通讯作者:
Zuk PA
Zuk PA
中科院分区:
生物学3区
文献类型:
--
作者:
Zuk PA

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2002年,加州大学洛杉矶分校的研究人员在《细胞分子生物学》上发表了一篇手稿,描述了一种从脂肪组织中分离出来的新型成体干细胞群体--脂肪来源干细胞(ASC)。从那时起,ASC一直是目前干细胞领域最受欢迎的成体干细胞群体之一。ASC具有多系中胚层潜能以及可能的外胚层和内胚层潜能,在实验室和临床上都有望成为多能ES细胞的替代品。在这篇回顾文章中,给出了ASC的历史视角,以及今天正在考虑的干细胞令人兴奋的新应用。
In 2002, researchers at UCLA published a manuscript in Molecular Biology of the Cell describing a novel adult stem cell population isolated from adipose tissue—the adipose-derived stem cell (ASC). Since that time, the ASC has gone on to be one of the most popular adult stem cell populations currently being used in the stem cell field. With multilineage mesodermal potential and possible ectodermal and endodermal potentials also, the ASC could conceivably be an alternate to pluripotent ES cells in both the lab and in the clinic. In this retrospective article, a historical perspective on the ASC is given together with exciting new applications for the stem cell being considered today.
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