Cellular mechanisms regulating [Ca2+]i smooth muscle.
Cellular mechanisms regulating [Ca2+]i smooth muscle.
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调节 [Ca2]i 平滑肌的细胞机制。
DOI：
--
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发表时间：
1989
影响因子：
18.2
通讯作者：
K. Saida
中科院分区：
文献类型：
--
作者：
C. Breemen;K. Saida
前面的章节建立了主要作用的Ca 2+在激活平滑肌收缩蛋白。在本章中，我们讨论了钙离子转运机制，决定细胞内钙离子浓度（[Ca2 +] U，从而调节平滑肌收缩。两个整合的膜系统参与平滑肌[Ca 2 +] i的控制：（a）质膜，其在膜电位（Em）和激动剂如神经递质激素和autocoids的控制下，和（B）肌浆网，其在第二信使的控制下。两种膜都形成对大约10，000-fold浓度梯度的屏障;因此，对Ca2+的渗透性的增加导致[Ca2 +] i的增加，而活性ATP激发的Ca2+泵送和可能的Na +-Ca2+交换导致[Ca2 +] i的减少。质膜Ca2+渗透性受电压门控Ca2+通道（VGC）和受体操作通道（ROC）的化学门控调节（11，83）。在某些情况下，激动剂还抑制Ca2+挤出泵（23）。根据Goldman方程，质膜电位由离子浓度梯度和渗透率决定，并通过K+通道的打开或关闭调节至接近K+平衡电位（11）。
The preceding chapters establish the primary role of Ca2+ in the activation of smooth muscle contractile proteins. In this chapter we discuss the Ca2+ transport mechanisms that determine the intracellular Ca2+ concentration ([Ca2+U and thus regulate smooth muscle contraction. Two integrated membrane systems are involved in the control of smooth muscle [Ca2+l;: (a) the plasmalemma, which is under the control of the membrane potential (Em) and agonists such as neurotransmitters hormones and autocoids, and (b) the sarcoplasmic reticulum, which is under the control of second messengers. Both membranes form a barrier to an approximately IO,OOO-foid concentration gradient; thus, an increase in permeability to Ca2+ leads to an increase in [Ca2+l;, while active ATP-fueled Ca2+ pumping and possibly Na+ -Ca2+ exchange leads to a decrease in [Ca2+l;. Plasmalemmal Ca2+ permeability is regulated by the voltage gated Ca2+ channels (VGCs) and by chemical gating of receptor operated channels (ROCs) (11, 83). In some cases, agonists also inhibit the Ca2+ extrusion pump (23). The mem brane potential is determined by ionic concentration gradients and per meabilities according to the Goldman equation and is regulated close to the K+ equilibrium potential by the opening or closing of K+ channels (11).
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影响因子：
2.6
作者：
JOHNS, A;LATEGAN, TW;ADAMS, DJ
通讯作者：
ADAMS, DJ
钙拮抗剂诱导血管舒张的机制。
DOI：
10.1146/annurev.pa.23.040183.002105
发表时间：
1983
影响因子：
12.5
作者：
Cauvin,C;Loutzenhiser,R;VanBreemen,C
通讯作者：
VanBreemen,C
平滑肌中的钙和单价离子。
DOI：
--
发表时间：
1982
期刊：
Federation proceedings
影响因子：
--
作者：
Somlyo,AP;Somlyo,AV;Shuman,H;Endo,M
通讯作者：
Endo,M
牛肾上腺皮质中肌醇三磷酸的结合位点。
DOI：
10.1016/0006-291x(85)90939-8
发表时间：
1985
影响因子：
3.1
作者：
Baukal,AJ;Guillemette,G;Rubin,R;Spät,A;Catt,KJ
通讯作者：
Catt,KJ