PhenomiR: a knowledgebase for microRNA expression in diseases and biological processes.

PhenomiR: a knowledgebase for microRNA expression in diseases and biological processes.
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DOI:
10.1186/gb-2010-11-1-r6
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发表时间:
2010-01-20
期刊:
影响因子:
12.3
通讯作者:
Theis FJ
Theis FJ
中科院分区:
生物学1区
文献类型:
--
作者:
Ruepp A;Kowarsch A;Schmidl D;Buggenthin F;Brauner B;Dunger I;Fobo G;Frishman G;Montrone C;Theis FJ

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PhenomiR是一个包含542项报告miRNA失调的研究的综合数据库,允许对miRNA表达变化进行大规模统计分析。近年来,microRNA被证实在生理和恶性过程中发挥重要作用。PhenomiR数据库http://mips.helmholtz-muenchen.de/phenomir提供了来自542项研究的数据,这些研究调查了疾病和生物过程中microRNA表达的失调,作为一种系统的,手动策划的资源。使用PhenomiR数据集,我们可以证明,根据疾病类型,来自细胞培养研究的独立信息与来自患者研究的结论形成对比。
PhenomiR is a comprehensive database of 542 studies reporting deregulation of miRNAs allowing large-scale statistical analysis of miRNA expression changes. In recent years, microRNAs have been shown to play important roles in physiological as well as malignant processes. The PhenomiR database http://mips.helmholtz-muenchen.de/phenomir provides data from 542 studies that investigate deregulation of microRNA expression in diseases and biological processes as a systematic, manually curated resource. Using the PhenomiR dataset, we could demonstrate that, depending on disease type, independent information from cell culture studies contrasts with conclusions drawn from patient studies.
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