Relocalization of DNA lesions to the nuclear pore complex.
Relocalization of DNA lesions to the nuclear pore complex.
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DOI：
10.1093/femsyr/fow095
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发表时间：
2016-12-01
影响因子：
3.2
通讯作者：
Su XA
中科院分区：
文献类型：
--
作者：
Freudenreich CH;Su XA
对酵母中对DNA损伤敏感的突变的早期筛查发现了核孔成分，但它们在DNA修复中的作用尚不清楚。在过去的十年中，研究表明，几种类型的持续性DNA损伤要么转移到核孔复合体(NPC)，要么转移到核膜(NE)。在这两个位置中，核孔似乎对DNA修复持续双链断裂、被侵蚀的端粒和扩展CAG重复序列中的叉状塌陷位置至关重要。利用细胞生物成像技术和酵母基因分析进行DNA修复，研究人员已经开始了解病变重新定位到鼻咽癌的方式和原因。在这里，我们回顾了转移到鼻咽癌的病变类型、转移的介体以及迄今为止所了解的转移的功能后果。新出现的主题是，重新定位到NPC调控重组，以影响修复途径的选择，并为耐修复的病变或DNA结构提供救援机制。作者回顾了DNA损伤到核孔复合体的重新定位如何影响修复途径的选择和促进基因组的稳定性。
Early screens in yeast for mutations exhibiting sensitivity to DNA damage identified nuclear pore components, but their role in DNA repair was not well understood. Over the last decade, studies have revealed that several types of persistent DNA lesions relocate to either the nuclear pore complex (NPC) or nuclear envelope (NE). Of these two sites, the nuclear pore appears to be crucial for DNA repair of persistent double-strand breaks, eroded telomeres and sites of fork collapse at expanded CAG repeats. Using a combination of cell biological imaging techniques and yeast genetic assays for DNA repair, researchers have begun to understand both the how and why of lesion relocation to the NPC. Here we review the types of lesions that relocate to the NPC, mediators of relocation and the functional consequences of relocation understood to date. The emerging theme is that relocation to the NPC regulates recombination to influence repair pathway choice and provide a rescue mechanism for lesions or DNA structures that are resistant to repair. The authors review how relocation of DNA lesions to the nuclear pore complex influences repair pathway choice and promotes genome stability.
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