Absence of immunoglobulins in rheumatoid cartilage-pannus junctions.
Absence of immunoglobulins in rheumatoid cartilage-pannus junctions.
复制标题
类风湿软骨-血管翳连接处缺乏免疫球蛋白。
DOI：
10.1002/art.1780230707
复制
发表时间：
1980
影响因子：
--
通讯作者：
M. Ziff
中科院分区：
文献类型：
--
作者：
S. Shiozawa;H. Jasin;M. Ziff
免疫复合物（IC）存在于类风湿关节软骨的浅表区域可能是一个重要的因素，在软骨的入侵由pannus。用免疫电镜观察了类风湿性关节软骨软骨-盘肌交界处被盘肌侵袭的情况，并用辣根过氧化物酶抗人免疫球蛋白（Ig）观察了IC的存在。我们观察到，尽管无pannus的软骨表面含有容易检测到的Ig沉积，但在研究的55例患者中，被pannus覆盖的区域未显示任何Ig。甚至在紧邻肠镜前缘的区域也是如此，这些区域可能只是最近才被肉芽组织侵入。荧光抗体紫外显微镜证实了上述结果。由此得出结论，类风湿膜侵入含有被困IC的游离软骨表面导致这些复合物的消失。
Immune complexes (IC) present in the superficial region of rheumatoid articular cartilage may be an important factor in the invasion of the cartilage by pannus. The presence of such IC at the cartilage-pannus junction in rheumatoid articular cartilage invaded by pannus was investigated by using immunoelectron microscopy with horseradish peroxidase anti-human immunoglobulin (Ig). It was observed that, although the pannus-free surface of the cartilage contained easily detectable deposits of Ig, the areas covered by pannus failed to show any Ig in the 5 5 patients studied. This was true even in areas immediately adjacent to the advancing edge of the pannus which presumably had only recently been invaded by the granulation tissue. These results were confirmed by fluorescent antibody ultraviolet microscopy. It was concluded that rheumatoid pannus invasion of the free cartilage surface containing trapped IC results in the disappearance of such complexes.
影响因子：
3.2
作者：
GRAHAM, RC;KARNOVSKY, MJ
通讯作者：
KARNOVSKY, MJ
影响因子：
3.2
作者：
MCLEAN, IW;NAKANE, PK
通讯作者：
NAKANE, PK