Lack of correlation between numbers of circulating t(14;18)-positive cells and response to first-line treatment in follicular lymphoma.
Lack of correlation between numbers of circulating t(14;18)-positive cells and response to first-line treatment in follicular lymphoma.
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滤泡性淋巴瘤循环 t(14;18) 阳性细胞数量与一线治疗反应之间缺乏相关性。
DOI：
10.1182/blood.v98.4.940
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发表时间：
2001
期刊：
影响因子：
20.3
通讯作者：
J. Raemaekers
中科院分区：
文献类型：
--
作者：
C. Mandigers;J. Meijerink;E. Mensink;E. Tönnissen;K. Hebeda;M. Bogman;J. Raemaekers
在滤泡性淋巴瘤中，聚合酶链反应（PCR）分析外周血和骨髓的t（14;18）状态被认为与复发患者的疾病活动性相关。报道了实时荧光定量PCR定量循环淋巴瘤细胞在一线治疗患者中的临床意义。连续监测34例未经治疗的滤泡性淋巴瘤患者，预处理外周血样本中可检测到t（14;18）阳性细胞。所有患者均采用标准化疗联合干扰素α -2b治疗。诱导治疗前后取血定量分析t（14;18）。在就诊时，每75,000个正常细胞中发现262t（14,18）个阳性细胞（范围1- 75,000）。循环肿瘤细胞数较少的患者更容易出现大体积病变（P = 0.02）。79%的患者对治疗有临床反应。28例患者中有22例，包括4例临床治疗失败的患者，治疗后循环t（14;18）阳性细胞的数量下降到无法检测或低水平。在其余有反应的患者中，循环肿瘤细胞在治疗后持续存在。这些关于循环t（14;18）阳性细胞的定量数据对一组接受非治愈性一线治疗的滤泡性淋巴瘤患者血液分子监测的有效性提出了质疑。治疗后外周血T（14;18）阳性细胞减少，与临床反应无关。因此，在滤泡性淋巴瘤中，应重新考虑所谓的分子缓解的意义。(血。2001;98:940 - 944)
In follicular lymphoma, the t(14;18) status of the peripheral blood and bone marrow analyzed by polymerase chain reaction (PCR) is assumed to correlate with disease activity in patients with relapsed disease. The clinical significance of quantitating circulating lymphoma cells by real-time PCR is reported in patients on first-line treatment. Thirty-four consecutive patients with previously untreated follicular lymphoma and detectable t(14;18)-positive cells in pretreatment peripheral blood samples were monitored. All patients were treated with standard chemotherapy in combination with interferon alfa-2b. Before and after induction therapy, blood samples were taken for quantitative analysis of t(14;18). At presentation, a median of 262 t(14;18)-positive cells per 75,000 normal cells was found (range, 1-75 000). Patients with lower numbers of circulating tumor cells more frequently had bulky disease (P =.02). Seventy-nine percent of the patients responded clinically to treatment. In 22 of 28 patients, including 4 patients in whom treatment had failed clinically, the number of circulating t(14;18)-positive cells decreased to undetectable or low levels after therapy. In the remaining responding patients, circulating tumor cells persisted after therapy. These quantitative data on circulating t(14;18)-positive cells call into question the usefulness of molecular monitoring of the blood in a group of patients with follicular lymphoma uniformly treated with a noncurative first-line regimen. T(14;18)-positive cells decreased in peripheral blood after treatment, irrespective of the clinical response. Therefore, the significance of so-called molecular remission should be reconsidered in follicular lymphoma. (Blood. 2001;98:940-944)
影响因子：
56.9
作者：
TSUJIMOTO, Y;FINGER, LR;CROCE, CM
通讯作者：
CROCE, CM
PCR 评估的分子反应是预测惰性滤泡性淋巴瘤无失败生存的最重要因素：MDACC 系列更新。
DOI：
--
发表时间：
2000
期刊：
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO.
影响因子：
--
作者：
Lopez-Guillermo,A;Cabanillas,F;McLaughlin,P;Smith,T;Hagemeister,F;Rodriguez,MA;Romaguera,JE;Younes,A;Sarris,AH;Preti,HA;Pugh,W;Lee,MS
通讯作者：
Lee,MS
滤泡性淋巴瘤患者首次缓解期间的高剂量治疗和自体骨髓移植。
影响因子：
20.3
作者：
Freedman,AS;Gribben,JG;Neuberg,D;Mauch,P;Soiffer,RJ;Anderson,KC;Pandite,L;Robertson,MJ;Kroon,M;Ritz,J;Nadler,LM
通讯作者：
Nadler,LM