Behaviorally conditioned suppression of a graft-versus-host response.
Behaviorally conditioned suppression of a graft-versus-host response.
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移植物抗宿主反应的行为条件抑制。
DOI：
10.1073/pnas.79.2.583
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发表时间：
1982
影响因子：
11.1
通讯作者：
Cohen,N
中科院分区：
文献类型：
--
作者：
Bovbjerg,D;Ader,R;Cohen,N
环磷酰胺（CY），以前用于调节抑制体液免疫反应，用于调节抑制移植物抗宿主反应（GvHR）。雌性（刘易斯x Brown Norway）F1大鼠通过在免疫前48天配对消耗糖精溶液和腹膜内注射50 mg/kg体重的CY来调节。在第0天，所有动物均注射从雌性刘易斯供体获得的脾白细胞悬液（每个足垫2 × 10（7）个细胞）。在第5天通过称重腘淋巴结来评估区域GvHR。条件动物给予单次低剂量注射CY和再暴露于条件刺激的淋巴结重量显着低于对照组，并没有显着差异，从动物给予三次注射CY在进行中的GvHR。结果表明，条件性免疫抑制，以前证明在胸腺依赖性和胸腺非依赖性体液免疫反应，也影响了腘GvHR，细胞免疫反应。
Cyclophosphamide (CY), previously used to condition suppression of humoral immune responses, was used to condition suppression of a graft-versus-host response (GvHR). Female (Lewis x Brown Norway) F1 rats were conditioned by pairing consumption of a saccharin solution with an intraperitoneal injection of CY at 50 mg/kg of body weight 48 days before immunization. On day 0, all animals were injected with a suspension of splenic leukocytes (2 x 10(7) cells per footpad) obtained from female Lewis donors. The regional GvHR was assessed on day 5 by weighing popliteal nodes. Conditioned animals given a single low-dose injection of CY and reexposed to conditioned stimuli had lymph node weights significantly lower than control groups and did not differ from animals given three injections of CY during the ongoing GvHR. The results suggest that conditioned immunosuppression, previously demonstrated in thymus-dependent and thymus-independent humoral immune responses, also affects the popliteal GvHR, a cellular immune response.
环磷酰胺的综述
影响因子：
8.8
作者：
B. Fox
通讯作者：
B. Fox