Periodontitis in cardiovascular disease patients with or without Marfan syndrome--a possible role of Prevotella intermedia.
Periodontitis in cardiovascular disease patients with or without Marfan syndrome--a possible role of Prevotella intermedia.
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DOI：
10.1371/journal.pone.0095521
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Hirata Y
中科院分区：
文献类型：
--
作者：
Suzuki J;Imai Y;Aoki M;Fujita D;Aoyama N;Tada Y;Wakayama K;Akazawa H;Izumi Y;Isobe M;Komuro I;Nagai R;Hirata Y
虽然牙周炎是心血管疾病（CVD）的危险因素，但牙周炎对马凡综合征（MFS）伴CVD的影响尚不清楚。本研究的目的是评估牙周细菌负荷和MSF与CVD之间的关系。受试者为MFS伴CVD患者（n = 47）;年龄和性别匹配的非MFS CVD患者（n = 48）作为对照。 记录全口临床测量结果，包括牙齿数量、牙周袋探诊深度（PD）、探诊出血（BOP）和社区牙周指数（CPI）。我们还评估了存在的三种牙周病原体，牙龈卟啉单胞菌，伴放线菌聚集菌，中间普雷沃菌使用聚合酶链反应测定。还测量了针对病原体的血清抗体滴度。我们发现，MFS与CVD患者牙周炎的发生率高于年龄和性别匹配的非MFS CVD对照组。与非MFS CVD对照组相比，MFS CVD患者的牙周炎发生率明显更高，剩余牙数更少，PD更深。此外，MFS合并CVD患者的血清抗中间普雷沃氏菌抗体滴度水平显著低于非MFS CVD患者。牙周炎可能影响MFS患者心血管并发症的病理生理。特定的牙周病原体可能是预防CVD发展的重要治疗靶点。
Although periodontitis is a risk factor for cardiovascular disease (CVD), the influence of periodontitis on Marfan syndrome (MFS) with CVD is unclear. The aim of this study was to assess the relationship between periodontal bacterial burden and MSF with CVD. The subjects were patients with MFS with CVD (n = 47); age and gender matched non-MFS CVD patients (n = 48) were employed as controls. Full-mouth clinical measurements, including number of teeth, probing of pocket depth (PD), bleeding on probing (BOP) and community periodontal index (CPI) were recorded. We also evaluated the existence of three periodontal pathogens, Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Prevotella intermedia using polymerase chain reaction assays. Serum antibody titers against the pathogens were also measured. We revealed that MFS with CVD patients had periodontitis more frequently than the age and gender matched non-MFS CVD control subjects. MFS with CVD patients had significantly severer periodontitis, fewer remaining teeth and deeper PD compared to the non-MFS CVD controls. Furthermore, the serum antibody titer level against Prevotella intermedia was significantly lower in MFS plus CVD patients compared to the non-MFS CVD patients. Periodontitis may influence the pathophysiology of cardiovascular complications in MFS patients. A specific periodontal pathogen might be a crucial therapeutic target to prevent CVD development.
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DOI：
10.1067/moe.2002.121430
发表时间：
2002-05-01
期刊：
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY
影响因子：
--
作者：
De Coster, PJA;Martens, LCM;De Paepe, A
通讯作者：
De Paepe, A
影响因子：
3.5
作者：
Jin, J. Y.;Choi, E. Y.;Kim, S. J.
通讯作者：
Kim, S. J.
影响因子：
--
作者：
Guan, Su-Min;He, Jian-Jun;Shu, Lei
通讯作者：
Shu, Lei
DOI：
10.1111/j.1745-7599.2009.00461.x
发表时间：
2009-12-01
影响因子：
--
作者：
Gonzales, Elizabeth A.
通讯作者：
Gonzales, Elizabeth A.
影响因子：
4
作者：
Loeys, Bart L.;Dietz, Harry C.;De Paepe, Anne M.
通讯作者：
De Paepe, Anne M.