The importance of timing of transitions for risk of regular smoking and nicotine dependence.
The importance of timing of transitions for risk of regular smoking and nicotine dependence.
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DOI：
10.1007/s12160-008-9051-x
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发表时间：
2008-08
影响因子：
3.8
通讯作者：
Merikangas, Kathleen
中科院分区：
文献类型：
--
作者：
Dierker, Lisa;He, Jianping;Kalaydjian, Amanda;Swendsen, Joel;Degenhardt, Louisa;Glantz, Meyer;Conway, Kevin;Anthony, James;Chiu, Wai Tat;Sampson, Nancy A.;Kessler, Ronald;Merikangas, Kathleen
研究主要吸烟里程碑(开始、每周和每天吸烟)之间的转换时间和速度与尼古丁依赖的开始和恢复之间的关系。分析基于2001年2月至2003年4月期间进行的具有全国代表性的面对面家庭调查--全国共病调查--复制(NCS-R)的数据。在吸烟者(n=5692)中，71.3%达到每周吸烟水平，67.5%达到每天吸烟水平。十分之四的吸烟者达到了尼古丁依赖的标准。开始每周和每天吸烟的时间越短，分别与向日常吸烟和尼古丁依赖的转变有关。每一次吸烟转变的风险在前一个里程碑开始后的一年内最高。康复与开始吸烟和发展成瘾之间的较长时间和较晚的开始吸烟年龄有关。这些发现揭示了吸烟和尼古丁依赖的临床过程。考虑到吸烟转变时机的重要性，通过针对青少年和年轻人在开始吸烟最近的几个月进行干预，可以进一步降低流行率。
To investigate the association between the timing and speed of transition among major smoking milestones (onset, weekly and daily smoking) and onset and recovery from nicotine dependence. Analyses are based on data from The National Comorbidity Survey-Replication (NCS-R), a nationally representative face-to-face household survey conducted between February 2001 and April 2003. Of those who had ever smoked (n=5,692), 71.3% had reached weekly smoking levels and 67.5% had reached daily smoking. Four in ten who had ever smoked met criteria for nicotine dependence. A shorter time since the onset of weekly and daily smoking was associated with a transition to both daily smoking and nicotine dependence, respectively. The risk for each smoking transition was highest within the year following the onset of the preceding milestone. Recovery was associated with a longer period of time between smoking initiation and the development of dependence and a later age of smoking onset. These findings shed light on the clinical course of smoking and nicotine dependence. Given the importance of timing of smoking transitions, prevalence may be further reduced through intervention targeted at adolescents and young adults in the months most proximal to smoking initiation.
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