Ex vivo sentinel node mapping in colon cancer combining blue dye staining and fluorescence imaging.
Ex vivo sentinel node mapping in colon cancer combining blue dye staining and fluorescence imaging.
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DOI：
10.1016/j.jss.2013.01.003
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发表时间：
2013-07
影响因子：
2.2
通讯作者：
Vahrmeijer, Alexander L.
中科院分区：
文献类型：
--
作者：
Schaafsma, Boudewijn E.;Verbeek, Floris P. R.;van der Vorst, Joost R.;Hutteman, Merlijn;Kuppen, Peter J. K.;Frangioni, John V.;van de Velde, Cornelis J. H.;Vahrmeijer, Alexander L.
The sentinel lymph node procedure has been proposed to improve nodal staging in colon cancer patients. The aim of this study was to assess the added value of near-infrared fluorescence imaging to conventional blue dye staining for ex vivo sentinel lymph node mapping. Twenty-two consecutive patients undergoing surgery for colon cancer were included. After tumor resection, a premixed cocktail of the near-infrared lymphatic tracer HSA800 and blue dye was submucosally injected around the tumor for detection of sentinel lymph nodes. The Mini-FLARE imaging system was used for fluorescence imaging. In 95% of the patients, at least one sentinel lymph node was identified. Overall, a total of 77 sentinel lymph nodes were identified, of which 77 were fluorescent (100%) and 70 (91%) were blue. Sentinel lymph nodes that were located deeper in the mesenteric fat could easily be located by NIR fluorescence. In 4 out of 5 patients with lymph node metastases, tumor cells were present in at least 1 of the sentinel lymph nodes. This study shows the successful use and added value of the near-infrared fluorescence tracer HSA800 to conventional blue dye for the ex vivo sentinel lymph node procedure in colon cancer.
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影响因子：
2.5
作者：
Schaafsma, Boudewijn E.;Mieog, J. Sven D.;Hutteman, Merlijn;Van der Vorst, Joost R.;Kuppen, Peter J. K.;Lowik, Clemens W. G. M.;Frangioni, John V.;Van de Velde, Cornelis J. H.;Vahrmeijer, Alexander L.
通讯作者：
Vahrmeijer, Alexander L.
影响因子：
3.7
作者：
Brouwer, Oscar R.;Klop, W. Martin C.;van Leeuwen, Fijs W. B.
通讯作者：
van Leeuwen, Fijs W. B.
影响因子：
3.7
作者：
Iddings, Douglas;Ahmad, Aziz;Bilchik, Anton
通讯作者：
Bilchik, Anton
影响因子：
3.2
作者：
Cahill, Ronan A.;Asakuma, Mitsuhiro;Marescaux, Jacques
通讯作者：
Marescaux, Jacques
影响因子：
--
作者：
Dawson, Katie;Wiebusch, Abigail;Thirlby, Richard C.
通讯作者：
Thirlby, Richard C.