A starring role for stellate cells in the pancreatic cancer microenvironment.
A starring role for stellate cells in the pancreatic cancer microenvironment.
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DOI：
10.1053/j.gastro.2012.11.037
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发表时间：
2013-06
期刊：
影响因子：
29.4
通讯作者：
Pandol SJ
中科院分区：
文献类型：
--
作者：
Apte MV;Wilson JS;Lugea A;Pandol SJ
胰腺导管腺癌是一种毁灭性的疾病，几十年来患者的预后并未得到改善。针对肿瘤细胞的治疗大多失败了。这可能是因为研究一直集中在癌细胞上，而基质对肿瘤进展的影响在很大程度上被忽视了。随着胰腺星状细胞的发现，胰腺癌研究的重点开始发生变化，胰腺星状细胞产生胰腺肿瘤基质。有令人信服的体外和体内证据表明胰腺星状细胞对胰腺癌的发展有影响；最近的几项临床前研究报告了针对胰腺星状细胞和基质的方法所取得的令人鼓舞的结果。我们综述了这些领域的背景和最新进展，以及未来可能改善治疗的重要研究方向。
Pancreatic ductal adenocarcinoma is a devastating disease, and patient outcomes have not improved in decades. Treatments that target tumor cells have largely failed. This could be because research has focused on cancer cells and the influence of the stroma on tumor progression has been largely ignored. The focus of pancreatic cancer research began to change with the identification of pancreatic stellate cells, which produce the pancreatic tumor stroma. There is compelling in vitro and in vivo evidence for the influence of pancreatic stellate cells on pancreatic cancer development; several recent preclinical studies have reported encouraging results with approaches designed to target pancreatic stellate cells and the stroma. We review the background and recent advances in these areas, along with important areas of future research that could improve therapy.
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DOI：
10.1097/pas.0b013e31824104c5
发表时间：
2012-03
期刊：
The American journal of surgical pathology
影响因子：
--
作者：
Chatterjee D;Katz MH;Rashid A;Wang H;Iuga AC;Varadhachary GR;Wolff RA;Lee JE;Pisters PW;Crane CH;Gomez HF;Abbruzzese JL;Fleming JB;Wang H
通讯作者：
Wang H
影响因子：
29.4
作者：
Froeling, Fieke E. M.;Feig, Christine;Kocher, Hemant M.
通讯作者：
Kocher, Hemant M.
影响因子：
4.3
作者：
Bach, D. R.;Kindler, J.;Strik, W. K.
通讯作者：
Strik, W. K.
影响因子：
4
作者：
Apte MV;Pirola RC;Wilson JS
通讯作者：
Wilson JS
影响因子：
29.4
作者：
Ceyhan, Gueralp O.;Bergmann, Frank;Friess, Helmut
通讯作者：
Friess, Helmut