Familial aggregation of irritable bowel syndrome: a family case-control study.
Familial aggregation of irritable bowel syndrome: a family case-control study.
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DOI：
10.1038/ajg.2010.116
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发表时间：
2010-04
期刊：
影响因子：
--
通讯作者：
Talley NJ
中科院分区：
文献类型：
--
作者：
Saito YA;Petersen GM;Larson JJ;Atkinson EJ;Fridley BL;de Andrade M;Locke GR 3rd;Zimmerman JM;Almazar-Elder AE;Talley NJ
肠易激综合征（IBS）在家庭中聚集，但之前的研究仅记录了患者的家族史。我们已经表明，患者相对IBS状态的协议是穷人。因此，我们进行了一项家庭病例对照研究，直接调查家庭成员的症状，以更好地量化IBS在家庭中的聚集性。本研究的目的是（i）比较病例亲属与对照亲属中IBS的患病率，以及（ii）确定性别、关系、主要症状和环境危险因素是否影响家族聚集性。肠易激综合征门诊患者、对照组及其一级亲属完成了肠道症状问卷。比较有家族史的病例和对照的百分比，并使用χ2检验计算比值比;使用logistic回归和广义估计方程计算亲属的复发风险。收集了477例病例、297例对照、1,492例病例亲属和936例对照亲属的数据。先证者的中位年龄为50岁，78%为女性。50%的病例组和27%的对照组至少有一个亲属患有IBS，比值比为2.75（95% CI：2.01-3.76，P < 0.0001）。当聚集估计重新评估分层的相对关系或先证者的性别，世代和性别的影响没有观察到。大便习惯的家族聚集性在腹泻中最弱，而在交替排便习惯中最强。IBS在家庭中聚集性很强。关联的强度确实因先证者的关系而有所不同，但配偶之间缺乏关联支持可能的遗传病因或共同的家庭环境暴露作为IBS的潜在原因。
Irritable bowel syndrome (IBS) clusters in families, but previous studies documented family history only from patients. We have shown that patient–relative agreement on IBS status is poor. Thus, we conducted a family case–control study with direct survey of symptoms from family members to better quantitate the aggregation of IBS in families. The aims of this study were to (i) compare the prevalence of IBS in case-relatives with control-relatives, and (ii) determine whether gender, relationship, predominant symptom, and environmental risk factors affect familial aggregation. Outpatients with IBS, matched controls, and their first-degree relatives completed a bowel symptom questionnaire. Percent of cases and controls with a family history were compared and odds ratios were computed using χ2 -test; recurrence risks to relatives were computed using logistic regression and generalized estimating equations. Data were collected from 477 cases, 297 controls, 1,492 case-relatives, and 936 control-relatives. Probands had a median age of 50 and 78% were women. 50% of case and 27% of control families had at least another relative with IBS yielding an odds ratio of 2.75 (95% CI: 2.01–3.76, P < 0.0001). When aggregation estimates were reevaluated stratifying by relative relationship or proband gender, generational and gender effects were not observed. Familial clustering by bowel habit was weakest for diarrhea, and strongest for alternating bowel habits. IBS aggregates strongly in families. The strength of the association does vary somewhat by relationship to proband, but the lack of association in spouses supports either a possible genetic etiology or a shared household environmental exposure as an underlying cause of IBS.
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影响因子：
24.5
作者：
WHORWELL, PJ;MCCALLUM, M;ROBERTS, CT
通讯作者：
ROBERTS, CT
影响因子：
9.8
作者：
Mohammed, I;Cherkas, LF;Trudgill, NJ
通讯作者：
Trudgill, NJ
DOI：
10.1111/j.1445-5994.1995.tb01894.x
发表时间：
1995-08-01
期刊：
AUSTRALIAN AND NEW ZEALAND JOURNAL OF MEDICINE
影响因子：
--
作者：
TALLEY, NJ;BOYCE, PM;PATERSON, KJ
通讯作者：
PATERSON, KJ
影响因子：
3.1
作者：
CHIBNALL, JT;TAIT, RC
通讯作者：
TAIT, RC
影响因子：
1.2
作者：
RADLOFF L S
通讯作者：
RADLOFF L S