Brief report: airways abnormalities and rheumatoid arthritis-related autoantibodies in subjects without arthritis: early injury or initiating site of autoimmunity?
Brief report: airways abnormalities and rheumatoid arthritis-related autoantibodies in subjects without arthritis: early injury or initiating site of autoimmunity?
复制标题
简要报告：无关节炎受试者的气道异常和类风湿性关节炎相关自身抗体：早期损伤或自身免疫的起始部位？
DOI：
10.1002/art.34344
复制
发表时间：
2012-06
影响因子：
--
通讯作者：
Deane, Kevin D.
中科院分区：
文献类型：
--
作者：
Demoruelle, M. Kristen;Weisman, Michael H.;Simonian, Philip L.;Lynch, David A.;Sachs, Peter B.;Pedraza, Isabel F.;Harrington, Annie R.;Kolfenbach, Jason R.;Striebich, Christopher C.;Pham, Quyen N.;Strickland, Colin D.;Petersen, Brian D.;Parish, Mark C.;Derber, Lezlie A.;Norris, Jill M.;Holers, V. Michael;Deane, Kevin D.
评价类风湿关节炎（RA）相关自身抗体（Ab）阳性但无炎性关节炎（IA）的受试者是否存在肺部异常。42例无IA但抗环瓜氨酸肽抗体和/或2种或2种以上类风湿因子同种型升高（RA特异性96%）的受试者、15例Ab（-）对照和12例早期血清阳性RA患者（病程<1年）接受了肺功能测定和高分辨率计算机断层扫描（HRCT）肺成像。Ab（+）受试者的中位年龄为54岁，52%为女性，38%为吸烟者（与Ab（-）对照组无显著差异）。无Ab（+）受试者在关节检查时发生IA。在HRCT上，76%的Ab（+）受试者有气道异常，包括支气管壁增厚、支气管扩张、小叶中心混浊和空气潴留，而Ab（-）对照组为33%（p=0.005）。与早期RA患者相比，Ab（+）受试者的肺部异常患病率和类型相似。2名患有气道疾病的Ab（+）受试者在肺部评价后约13个月发生了可分类为关节RA的IA。与炎症一致的气道异常在Ab（+）无IA的受试者中很常见，与早期RA中观察到的气道异常相似。这些发现表明，肺可能是自身免疫相关损伤的早期部位，并且可能是RA相关自身免疫产生的部位。需要进一步的研究来确定肺部炎症在RA发展中的机制作用。
To evaluate the presence of pulmonary abnormalities in subjects with rheumatoid arthritis (RA)-related autoantibody (Ab) positivity without inflammatory arthritis (IA). 42 subjects without IA but with elevations of anti-cyclic citrullinated peptide antibodies and/or 2 or more rheumatoid factor isotypes (a profile that is 96% specific for RA), 15 Ab(−) controls and 12 patients with early established seropositive RA (<1 year duration) underwent spirometry and high-resolution computed tomographic (HRCT) lung imaging. The median age of Ab(+) subjects was 54 years-old, 52% were female and 38% were smokers (not significantly different than Ab(−) controls). No Ab(+) subject had IA on joint examination. On HRCT, 76% of Ab(+) subjects had airways abnormalities including bronchial wall thickening, bronchiectasis, centrilobular opacities and air trapping, compared to 33% of Ab(−) controls (p=0.005). The Ab(+) subjects had similar prevalence and type of lung abnormalities compared to patients with early RA. Two Ab(+) subjects with airways disease developed IA classifiable as articular RA ~13 months after lung evaluation. Airways abnormalities that are consistent with inflammation are common in Ab(+) subjects without IA, and similar to airways abnormalities seen in early RA. These findings suggest that the lung may be an early site of autoimmune-related injury, and potentially a site of generation of RA-related autoimmunity. Further studies are needed to define the mechanistic role of lung inflammation in the development of RA.
登录
查看更多内容
影响因子：
9.6
作者：
Gupta, Sumit;Siddiqui, Salman;Brightling, Christopher E.
通讯作者：
Brightling, Christopher E.
影响因子：
2.1
作者：
Metafratzi, Z. M.;Georgiadis, A. N.;Efremidis, S. C.
通讯作者：
Efremidis, S. C.
影响因子：
15.9
作者：
Rangel-Moreno, Javier;Hartson, Louise;Randall, Troy D.
通讯作者：
Randall, Troy D.
影响因子：
3.4
作者：
Gizinski, Alison M.;Mascolo, Margherita;Loucks, Jennifer L.;Kervitsky, Alma;Meehan, Richard T.;Brown, Kevin K.;Holers, V. Michael;Deane, Kevin D.
通讯作者：
Deane, Kevin D.
影响因子：
19.7
作者：
Copley, Susan J.;Wells, Athol U.;Hansell, David M.
通讯作者：
Hansell, David M.