Mycobacterium paragordonae is an emerging pathogen in human pulmonary disease: clinical features, antimicrobial susceptibility testing and outcomes.
Mycobacterium paragordonae is an emerging pathogen in human pulmonary disease: clinical features, antimicrobial susceptibility testing and outcomes.
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副戈登分枝杆菌是人类肺部疾病的一种新兴病原体：临床特征、抗菌药物敏感性测试和结果
DOI：
10.1080/22221751.2022.2103453
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发表时间：
2022-12
影响因子：
13.2
通讯作者：
中科院分区：
文献类型：
--
作者：
目的：副ordonae分枝杆菌（Mycobacterium paragordonae， MPG）是一种新兴的、不常见的非结核分枝杆菌（Non-tuberculous mycobacteria， NTM），我们对其特征和预后知之甚少，因此我们构建了这项回顾性队列研究。方法：采用MALD-TOF质谱、多靶点联合基因测序和WGS法对MPG进行鉴定。收集临床资料，采用SLOMYCO平板进行药敏试验，采用Lowenstein-Jensen培养基进行最佳生长温度试验。结果：1730株ntm中分离到8株MPGs (0.46%)；MPG- pd患者平均年龄42.38±9.92岁，男性占37.5%，平均BMI为18.4±0.51 kg/m2。所有患者均有咳痰症状，CT图像以斑片状或条纹状阴影为主，MPG生长在25℃、30℃、37℃，最佳生长温度为37℃。MPGs对克拉霉素、利福布汀、阿米卡星、利奈唑胺、莫西沙星、复方新诺明和环丙沙星敏感，2株对利福平耐药。2例患者有随访信息，随访期间影像学保持稳定。结论：MPG-PD是一种罕见的NTM疾病，更容易发生在中年、女性和低BMI患者中。患者在症状和CT影像上均无特异性表现。MPG的最佳生长温度为37℃，MPG- pd对CLSI推荐的药物有极好的敏感性，病情稳定。
Objectives: Mycobacterium paragordonae (MPG) is an emerging and less common type of Non-tuberculous mycobacteria (NTM) and we know little about its characteristics and prognosis, hence we constructed this retrospective cohort study. Methods: MPG was identified using MALD-TOF MS, multi-target combined gene sequencing and WGS. Clinical information was collected, antimicrobial susceptibility testing was measured using the SLOMYCO panel, and optimal growth temperature testing was measured using Lowenstein-Jensen medium. Results: Eight MPGs were isolated from 1730 NTMs (0.46%); the mean age of MPG pulmonary disease (MPG-PD) patients was 42.38 ± 9.92 years, 37.5% were male, and the average BMI was 18.4 ± 0.51 kg/m2. All patients had the symptoms of cough and sputum and CT images mainly presented in patchy or streaky shadows, MPG grew at 25°C, 30°C and 37°C, and the optimal growth temperature is 37°C. MPGs were sensitive to clarithromycin, rifabutin, amikacin, linezolid, moxifloxacin, cotrimoxazole and ciprofloxacin, two isolates were resistant to rifampicin. Two patients had follow up information, their imaging remained stable during the follow-up. Conclusions: MPG-PD is a rare NTM disease and is more likely to develop in middle-aged, female, and low BMI patients. The patients present with no specific features within the symptoms as well as the CT imaging. The optimal growth temperature of MPG is at 37°C, MPG-PD has excellent sensitivity to drugs recommended by CLSI and presents with a stable disease.
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面部溃疡、流鼻血和 T-SPOT 阳性患者中的戈登分枝杆菌。
影响因子：
11.8
作者：
Chen Y;Jiang J;Jiang H;Chen J;Wang X;Liu W;Chen Z;Shi Y;Zhang W;Wang H
通讯作者：
Wang H
影响因子：
3.7
作者：
Azadi D;Shojaei H;Mobasherizadeh S;Naser AD
通讯作者：
Naser AD
影响因子：
7.3
作者：
Kim BJ;Jeong H;Seo H;Lee MH;Shin HM;Kim BJ
通讯作者：
Kim BJ
影响因子：
4.2
作者：
Pereira, Sonia Goncalves;Alarico, Susana;Empadinhas, Nuno
通讯作者：
Empadinhas, Nuno
影响因子：
6.9
作者：
Takajo, I;Iwao, C.;Okayama, A.
通讯作者：
Okayama, A.