Spontaneously arising red cells with a McLeod-like phenotype in normal donors.
Spontaneously arising red cells with a McLeod-like phenotype in normal donors.
复制标题
DOI：
10.1016/j.mrfmmm.2009.03.009
复制
发表时间：
2009-12-01
影响因子：
2.3
通讯作者：
Lee, Soohee
中科院分区：
文献类型：
--
作者：
Araten, David J.;Sanders, Katie J.;Pu, Jeffrey;Lee, Soohee
Very few human genes can be used to identify spontaneous inactivating somatic mutations. We hypothesized that because the XK gene is X-linked, it would be easy to identify spontaneously arising red cells with a phenotype resembling the McLeod syndrome, which results from inherited XK mutations. Here, by flow cytometry, we detect such phenotypic variants at a median frequency of 9 × 10−6 in neonatal cord blood samples and 39 × 10−6 in healthy adults (p = 0.004). It may be possible to further investigate the relationship between aging, mutations, and cancer using this approach.
登录
查看更多内容
影响因子：
11.2
作者：
Danek, A;Rubio, JP;Monaco, AP
通讯作者：
Monaco, AP
影响因子：
64.5
作者：
HO, MF;CHELLY, J;MONACO, AP
通讯作者：
MONACO, AP
影响因子：
6.5
作者：
Carbonnet, F;Hattab, C;Bertrand, O
通讯作者：
Bertrand, O
DOI：
10.1073/pnas.79.21.6617
发表时间：
1982-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
ALBERTINI, RJ;CASTLE, KL;BORCHERDING, WR
通讯作者：
BORCHERDING, WR
影响因子：
3.5
作者：
Peng, Jianbin;Redman, Colvin M.;Lee, Soohee
通讯作者：
Lee, Soohee