Control of hippocampal theta rhythm by serotonin: role of 5-HT2c receptors.
Control of hippocampal theta rhythm by serotonin: role of 5-HT2c receptors.
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DOI：
10.1016/j.neuropharm.2011.01.029
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发表时间：
2011-09
影响因子：
4.7
通讯作者：
Kocsis, Bernat
中科院分区：
文献类型：
--
作者：
Soerman, Elin;Wang, Dannie;Hajos, Mihaly;Kocsis, Bernat
海马体在学习和记忆中起着重要作用，并与许多疾病有关，包括癫痫、焦虑和精神分裂症。海马体网络的一个显著特征是能够产生有节奏的振荡。已知5 -羟色胺能调节在θ节律调节中起重要作用。5-HT2c受体代表了精神药理学的一个特定靶点，特别是，5-HT2c受体激动剂m-CPP的行为效应已经得到了彻底的测试。本研究使用该化合物和选择性5-HT2c受体拮抗剂SB-242084来阐明5-HT2c受体在海马振荡产生中的作用。记录自由活动大鼠不同行为和麻醉动物脑干刺激后的海马脑电图并监测θ波频率范围内的功率。我们发现，在自由运动的大鼠中，m-CPP抑制了海马的θ波节律，并且在快速眼动睡眠时的效果比清醒状态时更强。在氨基甲酸乙酯麻醉下，m-CPP以剂量依赖的方式降低自发性和诱发性θ节律的能力，而5-HT2c拮抗剂逆转了这一作用。本研究结果表明，5-HT2c受体是5-羟色胺能调节海马θ波振荡的重要因素，因此与这些受体的药物相互作用可以调节与边缘θ波活动相关的生理和病理过程。
The hippocampus plays an important role in learning and memory and has been implicated in a number of diseases, including epilepsy, anxiety and schizophrenia. A prominent feature of the hippocampal network is the capability to generate rhythmic oscillations. Serotonergic modulation is known to play an important role in the regulation of theta rhythm. 5-HT2c receptors represent a specific target of psychopharmacology and, in particular, the behavioural effects of the 5-HT2c receptor agonist m-CPP have been thoroughly tested. The present study used this compound and the selective 5-HT2c receptor antagonist SB-242084 to elucidate the role of 5-HT2c receptors in the generation of hippocampal oscillations. Hippocampal EEG was recorded and the power in the theta frequency range was monitored in different behaviours in freely moving rats and after brainstem stimulation in anesthetized animals. We found that in freely moving rats, m-CPP suppressed hippocampal theta rhythm and the effect was stronger during REM sleep than during waking theta states. Under urethane anesthesia, m-CPP decreased the power for both spontaneous and elicited theta rhythm in a dose-dependent manner and the 5-HT2c antagonist reversed this effect. The results of this study demonstrate that 5-HT2c receptors are important element of the serotonergic modulation of hippocampal theta oscillations and thus pharmacological interactions with these receptors can modulate physiological and pathological processes associated with limbic theta activity.
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影响因子：
4.7
作者：
Clemett, DA;Punhani, T;Fone, KCF
通讯作者：
Fone, KCF
DOI：
10.1111/j.1749-6632.1998.tb10175.x
发表时间：
1998-01-01
期刊：
ADVANCES IN SEROTONIN RECEPTOR RESEARCH
影响因子：
--
作者：
Heisler, LK;Chu, HM;Tecott, LH
通讯作者：
Tecott, LH
影响因子：
3.3
作者：
Liu, W;Alreja, M
通讯作者：
Alreja, M
影响因子：
7.3
作者：
Queree, P.;Peters, S.;Sharp, T.
通讯作者：
Sharp, T.
影响因子：
64.8
作者：
Kahana, MJ;Sekuler, R;Madsen, JR
通讯作者：
Madsen, JR