The influence of head motion on intrinsic functional connectivity MRI.
The influence of head motion on intrinsic functional connectivity MRI.
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DOI：
10.1016/j.neuroimage.2011.07.044
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发表时间：
2012-01-02
期刊：
影响因子：
5.7
通讯作者：
Buckner, Randy L.
中科院分区：
文献类型：
--
作者：
Van Dijk, Koene R. A.;Sabuncu, Mert R.;Buckner, Randy L.
功能连接磁共振成像（fcMRI）已广泛应用于探索群体和个体差异。一个混杂因素是头部运动。儿童比成人活动更多，老年人比年轻人活动更多，患者比对照组活动更多。同一群体内个体之间的头部运动差异很大。在这里，我们探讨了头部运动对 fcMRI 估计的影响。对 1000 名健康的年轻成年受试者进行平均头部位移、最大头部位移、微运动次数 (> 0.1 mm) 和头部旋转的估计，每个受试者在匹配的 3T 扫描仪上进行两次静息态运行扫描。受试者之间的大多数 fcMRI 变异与估计的头部运动无关。然而，头部运动对 fcMRI 网络测量具有显着的系统性影响。头部运动与默认控制网络和额顶控制网络的功能耦合减少有关，这两个网络的特征是关联皮层分布区域之间的耦合。其他网络测量随着运动而增加，包括局部功能耦合的估计以及左右运动区域之间的耦合——区域对有时用作建立特异性的研究中的对照。对头部运动水平略有不同的个体进行比较，会产生差异图，这些差异图可能会被误认为是其他情况下的神经元效应。在解释群体之间和个体之间的差异时，考虑这些影响非常重要。
Functional connectivity MRI (fcMRI) has been widely applied to explore group and individual differences. A confounding factor is head motion. Children move more than adults, older adults more than younger adults, and patients more than controls. Head motion varies considerably among individuals within the same population. Here we explored the influence of head motion on fcMRI estimates. Mean head displacement, maximum head displacement, the number of micro movements (> 0.1 mm), and head rotation were estimated in 1000 healthy, young adult subjects each scanned for two resting-state runs on matched 3T scanners. The majority of fcMRI variation across subjects was not linked to estimated head motion. However, head motion had significant, systematic effects on fcMRI network measures. Head motion was associated with decreased functional coupling in the default and frontoparietal control networks – two networks characterized by coupling among distributed regions of association cortex. Other network measures increased with motion including estimates of local functional coupling and coupling between left and right motor regions – a region pair sometimes used as a control in studies to establish specificity. Comparisons between groups of individuals with subtly different levels of head motion yielded difference maps that could be mistaken for neuronal effects in other contexts. These effects are important to consider when interpreting variation between groups and across individuals.
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