Persistent but less severe ataxia in long-term versus short-term abstinent alcoholic men and women: a cross-sectional analysis.

Persistent but less severe ataxia in long-term versus short-term abstinent alcoholic men and women: a cross-sectional analysis.
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长期与短期戒酒男性和女性的持续但不太严重的共济失调:横断面分析。

DOI:
10.1111/j.1530-0277.2011.01567.x
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发表时间:
2011
期刊:
Alcoholism, clinical and experimental research
影响因子:
--
通讯作者:
Fein,George
Fein,George
中科院分区:
--
文献类型:
--
作者:
Smith,Stan;Fein,George

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背景:步态紊乱和平衡障碍是慢性酒精中毒最一贯和最突出的后遗症之一。小样本纵向调查的结果提供了证据,证明戒酒可以部分恢复酗酒者的步态和平衡功能。方法:本研究采用横断面研究方法,对短期(6~15 周)戒酒者( 70例)和长期(至少18 月,平均 = 7.38 年)戒酒者( 82例)的步态和平衡功能进行评估。STAA和LTAA在终生饮酒量、家庭饮酒密度或教育年限方面没有不同。结果:我们的主要发现是:(I)STAA组持续的步态和平衡障碍,LTAA组的站立平衡障碍;(Ii)总体上,LTAA组在步态和平衡措施上的受损程度低于STAA组;以及(Iii)STAA(而不是LTAA)女性在没有视觉控制的站立平衡方面的表现比男性更差。结论:我们的结果表明,随着酒精的长期戒断,酗酒者的步态和平衡可以继续恢复,但仍存在缺陷,尤其是闭眼站立平衡。此外,我们的结果与女性比男性更严重的酒精诱导共济失调的情况是一致的,但这表明,随着长期禁欲的延长,女性的步态和平衡功能恢复到与男性相当的水平。
Background:Disturbed gait and balance are among the most consistent and salient sequelae of chronic alcoholism. Results of small sample longitudinal investigations have provided evidence that partial recovery of gait and balance functions in alcoholics may be achieved with abstinence. However, abstinence durations reported have been limited, and their power and generalizability have suffered from small sample sizes.Methods:In this study, we employed a cross‐sectional approach to assess gait and balance functions in short‐term (6 to 15 weeks) abstinent alcoholics (STAA;n= 70) and long‐term (minimum 18 months, mean = 7.38 years) abstinent alcoholics (LTAA;n= 82). STAA and LTAA did not differ with respect to lifetime alcohol consumption, family drinking density, or years of education. In addition, we examined the effects of gender and alcohol use variables.Results:Our main findings were: (i) persistent disturbed gait and balance in STAA and disturbed standing balance in LTAA; (ii) overall less impaired performance of LTAA compared with STAA on gait and balance measures; and (iii) worse performance of STAA (but not LTAA) women, compared with men, on standing balance without visual control.Conclusions:Our results suggest that alcoholics’ gait and balance can continue to recover with long abstinence from alcohol, but that deficits persist, especially in eyes‐closed standing balance. In addition, our results are consistent with more severe alcohol‐induced ataxia in women than in men but suggest that with extended abstinence, women recover gait and balance function to a level comparable with men.
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