The determinants of serum vitamin D levels in participants in a melanoma case-control study living in a temperate climate.
The determinants of serum vitamin D levels in participants in a melanoma case-control study living in a temperate climate.
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DOI：
10.1007/s10552-011-9827-3
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发表时间：
2011-10
影响因子：
2.3
通讯作者：
Newton-Bishop, Julia A.
中科院分区：
文献类型：
--
作者：
Davies, John R.;Chang, Yu-Mei;Snowden, Helen;Chan, May;Leake, Susan;Karpavicius, Birute;Haynes, Sue;Kukalizch, Kairen;Randerson-Moor, Juliette;Elliott, Faye;Barth, Julian;Kanetsky, Peter A.;Harland, Mark;Bishop, D. Timothy;Barrett, Jennifer H.;Newton-Bishop, Julia A.
关键词：
我们报告了一项英国黑色素瘤病例对照研究中血清维生素D水平的决定因素，该研究受益于详细的暴露和基因分型数据。阳光照射，补充维生素D，和SNPs报告与血清水平进行了评估，作为一个单一的血清25-羟基维生素D3测量调整季节，年龄，性别和体重指数的预测因子。调整后的分析表明，维生素D水平是次优的，特别是在阳光敏感的个体（-2.61 nmol/L，p = 0.03）和遗传的GC基因编码的维生素D结合蛋白（-5.79杂合子与野生型，p = <0.0001）的遗传变异。较高的水平与夏季周末（每三分位数+4.71 nmol/L，p = <0.0001）和炎热假期（每三分位数+4.17 nmol/L，p = <0.0001）的阳光照射有关。在平滑散点图中，在平均6小时/天的夏季周末阳光照射后，非阳光敏感个体的维生素D水平达到60 nmol/L，但在阳光敏感个体中没有。补充剂的使用者平均水平高出11.0 nmol/L，p = <0.0001，并且无论阳光照射如何都达到了最佳水平。阳光照射与维生素D水平增加有关，但平均水平超过60 nmol/L仅在报告长时间暴露（≥12小时/周末）的个体中达到。对阳光敏感的个体在没有补充的情况下没有达到最佳水平，因此，对于生活在温带气候中的大多数人群，特别是黑色素瘤患者，应该考虑补充。遗传变异的基因，如GC是一个强大的因素，和携带者的变异等位基因，因此可能需要更高水平的补充。本文的在线版本（doi：10.1007/s10552-011-9827-3）包含补充材料，可供授权用户使用。
We report the determinants of serum levels of vitamin D in a UK melanoma case–control study benefitting from detailed exposure and genotyping data. Sun exposure, supplemental vitamin D, and SNPs reported to be associated with serum levels were assessed as predictors of a single serum 25-hydroxyvitamin D3 measurement adjusted for season, age, sex, and body mass index. Adjusted analyses showed that vitamin D levels were sub-optimal especially in the sun-sensitive individuals (−2.61 nmol/L, p = 0.03) and for inheritance of a genetic variant in the GC gene coding for the vitamin D-binding protein (−5.79 for heterozygotes versus wild type, p = <0.0001). Higher levels were associated with sun exposure at the weekend in summer (+4.71 nmol/L per tertile, p = <0.0001), and on hot holidays (+4.17 nmol/L per tertile, p = <0.0001). In smoothed scatter plots, vitamin D levels of 60 nmol/L in the non-sun-sensitive individuals were achieved after an average 6 h/day summer weekend sun exposure but not in the sun-sensitive individuals. Users of supplements had levels on average 11.0 nmol/L higher, p = <0.0001, and achieved optimal levels irrespective of sun exposure. Sun exposure was associated with increased vitamin D levels, but levels more than 60 nmol/L were reached on average only in individuals reporting lengthy exposure (≥12 h/weekend). The sun-sensitive individuals did not achieve optimal levels without supplementation, which therefore should be considered for the majority of populations living in a temperate climate and melanoma patients in particular. Inherited variation in genes such as GC is a strong factor, and carriers of variant alleles may therefore require higher levels of supplementation. The online version of this article (doi:10.1007/s10552-011-9827-3) contains supplementary material, which is available to authorized users.
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影响因子：
4.2
作者：
Fang, Yue;van Meurs, Joyce B. J.;Arp, Pascal;van Leeuwen, Johannes P. T.;Hofman, Albert;Pols, Huibert A. P.;Uitterlinden, Andre G.
通讯作者：
Uitterlinden, Andre G.
影响因子：
3.5
作者：
Ahn J;Yu K;Stolzenberg-Solomon R;Simon KC;McCullough ML;Gallicchio L;Jacobs EJ;Ascherio A;Helzlsouer K;Jacobs KB;Li Q;Weinstein SJ;Purdue M;Virtamo J;Horst R;Wheeler W;Chanock S;Hunter DJ;Hayes RB;Kraft P;Albanes D
通讯作者：
Albanes D
影响因子：
6.4
作者：
Downing, Amy;Yu, Xue Qin;Forman, David
通讯作者：
Forman, David
影响因子：
7.7
作者：
Chang, Yu-mei;Barrett, Jennifer H.;Newton-Bishop, Julia A.
通讯作者：
Newton-Bishop, Julia A.
影响因子：
4.1
作者：
Adami, Silvano;Bertoldo, Francesco;Rini, Giovanni Battista
通讯作者：
Rini, Giovanni Battista