Surgical results of resectable small cell lung cancer.
Surgical results of resectable small cell lung cancer.
复制标题
DOI：
10.1111/1759-7714.12154
复制
发表时间：
2015-03
期刊：
影响因子：
2.9
通讯作者：
Maehara Y
中科院分区：
文献类型：
--
作者：
Kawano D;Okamoto T;Fujishita T;Suzuki Y;Kitahara H;Shimamatsu S;Maehara Y
小细胞肺癌（SCLC）患者的标准治疗是化疗和放疗，即使是局限性疾病患者也是如此。为了明确手术切除在局限性小细胞肺癌患者中的作用，我们调查了诊断为局限性疾病（LD）小细胞肺癌患者的结局。回顾性分析1974年4月至2012年3月间57例LD SCLC患者的手术切除记录。其中有6名女性和51名男性，中位年龄为63.5岁。总体5年生存率为28.6%（中位数，18.2个月）。P-II期和III期患者的生存率显著低于P-I期患者（13.4% vs. 43.4%，P = 0.0036）。然而，未发现c期与生存相关。接受肺切除术的患者的结局明显差于接受其他外科手术的患者（0.0% vs. 32.0%，P = 0.0002）。在多变量考克斯比例风险分析中，p-II或III期（风险比[HR] 3.040 P = 0.0017）和肺切除术（HR 6.177，P = 0.00159）是不良生存结局的显著独立预测因素。手术治疗可以考虑在小细胞肺癌患者病理证实的N 0状态，但应避免肺切除术。
The standard of care for patients with small cell lung cancer (SCLC) is chemotherapy and radiotherapy, even for patients with limited disease. To define the role of surgical resection in patients with limited SCLC, we investigated the outcomes of patients diagnosed with limited-stage disease (LD) SCLC. The records of 57 LD SCLC patients who underwent surgical resection from April 1974 to March 2012 were retrospectively analyzed. There were six women and 51 men, with a median age of 63.5 years. The overall five-year survival rate was 28.6% (median, 18.2 months). The p-stage II and III patients had a significantly worse survival than the p-stage I patients (13.4% vs. 43.4%, P = 0.0036). However, the c-stage was not found to correlate with survival. Patients who underwent pneumonectomy had a significantly worse outcome than those who underwent other surgical procedures (0.0% vs. 32.0%, P = 0.0002). In a multivariate Cox proportional hazards analysis, p-stage II or III (hazard ratio [HR] 3.040 P = 0.0017) and pneumonectomy (HR 6.177, P = 0.00159) were significant independent predictors of an adverse survival outcome. Surgical treatment can be considered in SCLC patients with pathologically proven N0 status, although pneumonectomy should be avoided.
登录
查看更多内容
影响因子：
4.6
作者：
Inoue, M;Miyoshi, S;Matsuda, H
通讯作者：
Matsuda, H
影响因子：
3.4
作者：
Badzio, A;Kurowski, K;Jassem, J
通讯作者：
Jassem, J
影响因子：
20.4
作者：
Lim, Eric;Belcher, Elizabeth;Goldstraw, Peter
通讯作者：
Goldstraw, Peter
影响因子：
4.6
作者：
HOLMES, CE;RUCKDESCHEL, JC;LONG, S
通讯作者：
LONG, S
影响因子：
2.5
作者：
HARA, N;OHTA, M;KAWASAKI, M
通讯作者：
KAWASAKI, M