Changes of Anti-tuberculosis Herbs Formula during Past Three Decades in Contrast to Ancient Ones
Changes of Anti-tuberculosis Herbs Formula during Past Three Decades in Contrast to Ancient Ones
复制标题
近三十年来抗结核中药方剂的变迁与古方对比
DOI：
10.1007/s11655-020-3475-y
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发表时间：
2020-07
影响因子：
2.9
通讯作者：
Sun Zhaogang
中科院分区：
文献类型：
--
作者：
Xu Yuhui;Dai Guangming;Tang Shihuan;Yang Hongjun;Sun Zhaogang
目的：调查草药治疗结核病 (TB) 的演变并鼓励抗结核药物的发现和开发。方法：本研究通过检索万方数据知识服务平台、中国国家知识基础数据库（CNKI）、中国科技期刊数据库（VIP）和中文生物医学文献检索系统（SinoMed）4个数据库，从《中药方剂词典》中收集了477个古代中药方剂，并收集了172个现代中药方剂（1986年至2016年）。我们将搜索范围限制为中文出版物。使用中医药传承支持系统第二版软件进行进一步的数据分析。结果：古方477方中425味药，现代方172方中257味药。前30种药材中，有一半是现代和古代处方所共有的。它们是麦冬、黄芪、川贝母、熟地、茯苓、当归、熟地黄、桔梗、白芍、五味子、白术、知母、地骨皮和黄芩。现代和古方中仅发现两组相关系数较高的药材，即干地黄配麦冬、麦冬配熟地黄。现代和古方中分别有9种和15种核心药物组合，但没有在现代和古方中同时发现一种。结论：虽然方剂中的药组和药用组合存在较大差异，但排名前30位的药材中有一半在现代和古代处方中都有发现。现代和古代处方中的核心草药组合可以帮助我们改进治疗结核病的处方。
Objective: To investigate the evolution of herbal medicine in treating tuberculosis (TB) and encourage anti-TB drug discovery and development. Methods: In this study, 477 ancient traditional Chinese medicine formulae were collected from the Dictionary of Traditional Chinese Medicine Prescriptions and 172 modern Chinese medicine formulae (from 1986 to 2016) were collected by searching 4 databases: WanFang Data Knowledge Service Platform, China National Knowledge Infrastructure Database (CNKI), China Science and Technology Journal Database (VIP) and Chinese Bio-medical Literature and Retrieval System (SinoMed) in Chinese. We restricted the search to publications in Chinese. Further data analysis was done using the Traditional Chinese Medicine Inheritance Support System version 2 Software. Results: There were 425 herbs in the 477 ancient formulae and 257 herbs in the 172 modern formulae. Half of the top 30 herbs were shared by both modern and ancient prescriptions. They are Radix Ophiopogonis, Astragalus membranaceus, Fritillaria cirrhosa, Dried rehmannia glutinosa, Poria cocos, Angelica sinensis, Prepared rehmannia glutinosa, Platycodon Root, Radix paeoniae alba, Schisandra chinensis, Bighead atractylodes rhizome, Rhizoma anemarrhenae, Cortex lycii radicis and Radix Scutellariae. Only two groups of herbs with a high correlation coefficient were found in both modern and ancient prescriptions, the Dried rehmannia glutinosa with Radix ophiopogonis, and Radix ophiopogonis with Prepared rehmannia glutinosa. There were 9 and 15 core herb combinations in modern and ancient prescriptions, respectively, but no one was found simutaniously in both modern and ancient prescriptions. Conclusions: Although there were wide variations in the herb groups and herb combinations in the formulae, half of the top 30 herbs were found in both modern and ancient prescriptions. The core herb combinations in modern and ancient prescriptions could help us to improve the priscription for treatment of TB.
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影响因子：
1.6
作者：
Chen, Jianxin;Xi, Guangcheng;Wang, Wei
通讯作者：
Wang, Wei
影响因子：
4.2
作者：
C. A. Gray;John A. Johnson;D. Webster
通讯作者：
C. A. Gray;John A. Johnson;D. Webster
DOI：
10.4268/cjcmm20121102
发表时间：
2012-06
期刊：
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
影响因子：
--
作者：
X. Zhang;Lanping Guo;Luqi Huang
通讯作者：
X. Zhang;Lanping Guo;Luqi Huang
影响因子：
1.6
作者：
Yang, Hongjun;Chen, Jianxin;Yi, Jianqiang
通讯作者：
Yi, Jianqiang
DOI：
10.4268/cjcmm20102430
发表时间：
2010-12
期刊：
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
影响因子：
--
作者：
Shihuan Tang;Jianxin Chen;Hongjun Yang;Bo Wang
通讯作者：
Shihuan Tang;Jianxin Chen;Hongjun Yang;Bo Wang