Benchmark dose profiles for joint-action quantal data in quantitative risk assessment.
Benchmark dose profiles for joint-action quantal data in quantitative risk assessment.
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DOI：
10.1111/j.1541-0420.2012.01811.x
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发表时间：
2012-12
期刊：
影响因子：
1.9
通讯作者：
Piegorsch WW
中科院分区：
文献类型：
--
作者：
Deutsch RC;Piegorsch WW
基准分析是公共卫生风险分析中广泛使用的工具。其中，对引起预先指定的基准反应(BMR)的最低暴露水平的估计，称为基准剂量(BMDS)，对于对单一刺激的不良反应的情况是很好理解的。然而，对于同时研究两个代理人的情况，基准方法的开发程度要低得多。本文演示了如何将基准建模范式从单一剂量设置扩展到联合行动、两剂研究。重点是以比例表示的反应结果。扩展单次接触设置，风险的表示基于涉及两个因素的联合作用剂量-反应模型。在这种模型的基础上，定义了基准分布(BMP)的概念--两种药物达到规定的BMR的单剂量BMD的二维模拟--用于定量风险描述和评估。由此产生的联合低剂量指南可以在处理低水平暴露于危险制剂组合时改进公共卫生规划和风险监管。
Benchmark analysis is a widely used tool in public health risk analysis. Therein, estimation of minimum exposure levels, called Benchmark Doses (BMDs), that induce a pre-specified Benchmark Response (BMR) is well understood for the case of an adverse response to a single stimulus. For cases where two agents are studied in tandem, however, the benchmark approach is far less developed. This paper demonstrates how the benchmark modeling paradigm can be expanded from the single-dose setting to joint-action, two-agent studies. Focus is on response outcomes expressed as proportions. Extending the single-exposure setting, representations of risk are based on a joint-action dose-response model involving both agents. Based on such a model, the concept of a benchmark profile (BMP) – a two-dimensional analog of the single-dose BMD at which both agents achieve the specified BMR – is defined for use in quantitative risk characterization and assessment. The resulting, joint, low-dose guidelines can improve public health planning and risk regulation when dealing with low-level exposures to combinations of hazardous agents.
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影响因子：
3.4
作者：
Nitcheva, Daniela K.;Piegorsch, Walter W.;West, R. Webster
通讯作者：
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