Comparison of clinical characteristics between patients with coronavirus disease 2019 (COVID-19) who retested RT-PCR positive versus negative: a retrospective study of data from Nanjing.
Comparison of clinical characteristics between patients with coronavirus disease 2019 (COVID-19) who retested RT-PCR positive versus negative: a retrospective study of data from Nanjing.
复制标题
DOI：
10.21037/jtd.2020.04.17
复制
发表时间：
2020-11
影响因子：
2.5
通讯作者：
Wei H
中科院分区：
文献类型：
--
作者：
Liu Y;Ding N;Zhou S;Chen C;Huang S;Lv Y;Jiao D;Zheng Y;Hu Z;Xu C;Chen W;Dai H;Sun W;Cheng C;Lv R;Cheng J;Ye Z;Li Z;Yi Y;Wei H
2019 年冠状病毒病 (COVID-19) 患者的流行病学和临床特征已有报道。然而，严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 的 RT-PCR 重新检测呈阳性的患病率以及相关的患者特征仍不清楚。在这项回顾性研究中，我们纳入了2020年1月20日至2020年2月16日期间在南京市公共卫生中心接受治疗的90例确诊的COVID-19病例。所有患者均完成了 COVID-19 治疗，并在治疗完成后 4-20 天通过 RT-PCR 重新检测了 SARS-CoV-2。比较 RT-PCR 复检阳性与阴性患者的临床特征，并分析复检阳性的预测因素。阳性重新测试采用受试者工作特征曲线下面积 (AUC) 进行建模。研究人群的年龄范围为0.8-97岁，所有患者均治愈或出现好转。治疗完成后 4-20 天，共有 10 名患者 (11%) 通过 RT-PCR 重新检测呈阳性。与复检阴性患者相比，复检阳性患者入院前发热比例较低，入院后发热比例较高，双侧肺部感染比例较低，白细胞（WBC）计数和肌酸磷酸激酶较高，超敏C反应蛋白（hs-CRP）、白细胞介素6和红细胞沉降率较低（均P<0.05）。上述八个关键变量的逻辑回归分析表明，较低的 hs-CRP 和较高的 WBC 与 RT-PCR 重新检测呈阳性独立相关。 hs-CRP 和 WBC 的组合可预测重新检测呈阳性，AUC 为 0.859。通过 RT-PCR 重新检测出 SARS-CoV-2 呈阳性的 COVID-19 患者症状较轻，血液检测结果也较好。 hs-CRP 和 WBC 的组合可以预测 RT-PCR 重新检测呈阳性；然而，其敏感性和特异性还需进一步研究。
The epidemiological and clinical characteristics of patients with coronavirus disease 2019 (COVID-19) have been reported. However, the prevalence of retesting positive by RT-PCR for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the associated patient characteristics, remain unclear. We included 90 confirmed cases of COVID-19 treated in the Nanjing Public Health Center from January 20, 2020 to February 16, 2020 in this retrospective study. All patients completed treatment for COVID-19 and were retested by RT-PCR for SARS-CoV-2 4–20 days after completion of therapy. The clinical characteristics between patients with who retested positive versus negative by RT-PCR were compared, and the factors predictive of positive retesting were analyzed. Positive retesting was modeled with the area under the receiver operating characteristic curve (AUC). The age range of the study population was 0.8–97 years, and all patients were cured or showed improvement. A total of 10 (11%) patients retested positive by RT-PCR 4–20 days after completion of therapy. As compared with patients who retested negative, those who retested positive had a lower percentage of pre-admission fever, a higher percentage of post-admission fever, a lower percentage of bilateral lung infection, higher white blood cell (WBC) count and creatine phosphokinase, and lower hypersensitive c-reactive protein (hs-CRP), interleukin-6 and erythrocyte sedimentation rates (all P<0.05). Logistic regression analysis of the above eight key variables showed that lower hs-CRP and higher WBC were independently associated with positive retesting by RT-PCR. A combination of hs-CRP and WBC were predictive of positive retesting, with an AUC of 0.859. Patients with COVID-19 who retested positive by RT-PCR for SARS-CoV-2 had mild symptoms and better blood testing results. A combination of hs-CRP and WBC may predict positive retesting by RT-PCR; however, the sensitivity and specificity should be studied further.
登录
查看更多内容
影响因子：
168.9
作者：
Huang, Chaolin;Wang, Yeming;Cao, Bin
通讯作者：
Cao, Bin
影响因子：
11.8
作者：
Qin, Chuan;Zhou, Luoqi;Tian, Dai-Shi
通讯作者：
Tian, Dai-Shi
DOI：
10.3760/cma.j.cn112147-20200229-00219
发表时间：
2020-04-12
期刊：
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
影响因子：
--
作者：
Zhou, L;Liu, K;Liu, H G
通讯作者：
Liu, H G
影响因子：
12.7
作者：
Wong, Justin;Koh, Wee Chian;Naing, Lin
通讯作者：
Naing, Lin
中国武汉市 138 例 2019 新型冠状病毒感染肺炎住院患者的临床特征。
影响因子：
120.7
作者：
Wang, Dawei;Hu, Bo;Peng, Zhiyong
通讯作者：
Peng, Zhiyong