Large differences in substitutional pattern and evolutionary rate of 12S ribosomal RNA genes.
Large differences in substitutional pattern and evolutionary rate of 12S ribosomal RNA genes.
复制标题
12S核糖体RNA基因的替代模式和进化速率存在巨大差异。
DOI：
10.1093/oxfordjournals.molbev.a025660
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发表时间：
1996
影响因子：
10.7
通讯作者：
C. Mcintosh
中科院分区：
文献类型：
--
作者：
C. Simon;L. Nigro;J. Sullivan;K. Holsinger;A. Martín;A. Grapputo;A. Franke;C. Mcintosh
我们利用果蝇、周期性蝉和原始灵长类动物证明，基于动物线粒体小亚基 (12S) rRNA 基因的分子钟以显着不同的相对速率计时，具体取决于检查的分类单元和基因区域。果蝇通常用作模型分类群，其进化方式非常独特，12S 基因 3' 半部分的大多数位点显然保持不变。线粒体大亚基 rRNA 基因 (16S) 的类似 3' 半区似乎也受到类似的限制。令人惊讶的是，这些在所有动物中都受到高度限制的区域在果蝇中应该受到更多限制，特别是当果蝇线粒体基因组作为一个整体没有表现出类似的速率减慢时。这种极端的 12S 速率减慢在周期性蝉或原始灵长类动物中并不明显，并且似乎与强大的结构和功能限制有关，而不是与突变率降低有关。最后，果蝇第三域缓慢的平均进化速度并不意味着少数可变位点缺乏多重命中。
We demonstrate using Drosophila, periodical cicadas, and hominid primates, that the molecular clock based on animal mitochondrial small-subunit (12S) rRNA genes ticks at significantly different relative rates depending on which taxa and which region of the gene are examined. Drosophila, which are commonly used as model taxa, are evolving in a highly peculiar manner with the majority of sites in the 3' half of the 12S gene apparently invariant. The analogous 3' half of the mitochondrial large-subunit rRNA gene (16S) appears to be similarly constrained. It is surprising that these regions that are already highly constrained in all animals should be even more constrained in Drosophila, especially when the Drosophila mitochondrial genome as a whole does not display a similar rate slowdown. This extreme 12S rate slowdown is not apparent in periodical cicadas or hominid primates and appears to be related to strong structural and functional constraints rather than a depressed mutation rate. Finally, the slow average rate of evolution in the third domain of Drosophila does not imply that the few variable sites lack multiple hits.
影响因子：
10.7
作者：
K. Tamura
通讯作者：
K. Tamura
影响因子：
3.3
作者：
S. Muse;B. Weir
通讯作者：
S. Muse;B. Weir
当替代率随位点变化时，最大似然法、邻接法和最大简约法的相对效率。
影响因子：
10.7
作者：
Tateno,Y;Takezaki,N;Nei,M
通讯作者：
Nei,M