Physiologically Based Pharmacokinetic Modeling of Nanoparticles.
Physiologically Based Pharmacokinetic Modeling of Nanoparticles.
复制标题
DOI：
10.1016/j.xphs.2018.10.037
复制
发表时间：
2019-01
影响因子：
3.8
通讯作者：
Cao Y
中科院分区：
文献类型：
--
作者：
Yuan D;He H;Wu Y;Fan J;Cao Y
纳米颗粒通常被设计用于改善小分子的药代动力学特征和组织分布，以延长其体循环、靶向特定组织或拓宽治疗窗口。纳米颗粒的多功能性通常被认为是一种优势，但与相同分子的常规制剂相比，也导致了独特和复杂的体内处置特性。基于生理学的药代动力学（PBPK）建模与药效学（PD）建模相结合时，已成为表征和预测各种类型药物的全身分布、目标暴露和功效/毒性的有用工具。在这里，我们回顾了纳米粒子的独特的配置特性，评估PBPK建模如何考虑到纳米粒子的独特配置属性，并评论PBPK建模在表征和预测纳米粒子的配置和生物效应方面的应用和挑战。
Nanoparticles are frequently designed to improve the pharmacokinetics profiles and tissue distribution of small molecules in order to prolong their systemic circulation, target specific tissue, or widen the therapeutic window. The multi-functionality of nanoparticles is frequently presented as an advantage but also results in distinct and complicated in vivo disposition properties compared to a conventional formulation of the same molecules. Physiologically-based pharmacokinetic (PBPK) modeling has been a useful tool in characterizing and predicting the systemic disposition, target exposure, and efficacy/toxicity of various types of drugs when coupled with pharmacodynamics (PD) modeling. Here, we review the unique disposition characteristics of nanoparticles, assess how PBPK modeling takes into account the unique disposition properties of nanoparticles, and comment on the applications and challenges of PBPK modeling in characterizing and predicting the disposition and biological effects of nanoparticles.
登录
查看更多内容
DOI：
10.1186/2193-9616-1-8
发表时间：
2013
期刊：
In silico pharmacology
影响因子：
--
作者：
Quignot N
通讯作者：
Quignot N
影响因子：
14
作者：
He, Zhijian;Wan, Xiaomeng;Schulz, Anita;Bludau, Herdis;Dobrovolskaia, Marina A.;Stern, Stephan T.;Montgomery, Stephanie A.;Yuan, Hong;Li, Zibo;Alakhova, Dania;Sokolsky, Marina;Darr, David B.;Perou, Charles M.;Jordan, Rainer;Luxenhofer, Robert;Kabanov, Alexander V.
通讯作者：
Kabanov, Alexander V.
影响因子：
17.4
作者：
Gustafson HH;Holt-Casper D;Grainger DW;Ghandehari H
通讯作者：
Ghandehari H
影响因子：
5
作者：
Bachler, Gerald;von Goetz, Natalie;Hungerbuhler, Konrad
通讯作者：
Hungerbuhler, Konrad
影响因子：
2
作者：
Hashimoto, Yosuke;Shimizu, Taro;Kiwada, Hiroshi
通讯作者：
Kiwada, Hiroshi