The association of pipe and cigar use with cotinine levels, lung function, and airflow obstruction: a cross-sectional study.
The association of pipe and cigar use with cotinine levels, lung function, and airflow obstruction: a cross-sectional study.
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DOI：
10.7326/0003-4819-152-4-201002160-00004
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发表时间：
2010-02-16
影响因子：
39.2
通讯作者：
Barr RG
中科院分区：
文献类型：
--
作者：
Rodriguez J;Jiang R;Johnson WC;MacKenzie BA;Smith LJ;Barr RG
吸烟是慢性阻塞性肺疾病的主要原因，但关于其他吸烟技术的贡献的研究很少。我们假设，烟斗和雪茄吸烟与可替宁水平升高、肺功能下降和气流阻塞的几率增加有关。横断面研究。以人口为基础的样本，来自美国六个社区。动脉粥样硬化的多种族研究(MESA)招募了年龄在45-84岁之间、没有临床心血管疾病的男性和女性。梅萨肺研究按照美国胸科学会指南进行了肺活量测定，并通过免疫测定法测定了尿可替宁水平。烟斗年和雪茄年的计算方法是从自我报告的戒烟年龄到戒烟年龄(或当前使用者的当前年龄)×每天烟斗或雪茄。在3528名参与者中，8%的人报告吸烟(中位数15烟斗年)，11%的人报告雪茄吸烟(中位数6雪茄年)，52%的人报告吸烟(中位数18包年)。自我报告的烟斗和雪茄吸烟者与从不吸烟者相比，尿可替宁水平升高。烟斗年与一秒用力呼气量(FEV1)的下降有关，雪茄年与FEV1和FEV1与用力肺活量的比率下降有关。与无吸烟史的受试者相比，吸烟斗或雪茄的受试者无论是否吸烟(优势比为3.43；95%CI：1.75，6.71；P<；0.001)或从未吸烟(优势比为2.31；95%CI：1.04，5.11；P=0.039)，都有更高的气流阻塞风险。横断面设计。吸烟斗和雪茄会增加尿可替宁水平，并与肺功能下降和气流阻塞的几率增加有关，即使是在从不吸烟的参与者中也是如此。
Cigarette smoking is the major cause of chronic obstructive pulmonary disease but studies on the contribution of other smoking techniques are sparse. We hypothesized that pipe and cigar smoking was associated with elevated cotinine levels, decrements in lung function and increased odds of airflow obstruction. Cross-sectional study. Population-based sample from six US communities. The Multi-Ethnic Study of Atherosclerosis (MESA) recruited men and women ages 45-84 years without clinical cardiovascular disease. The MESA Lung Study measured spirometry following American Thoracic Society guidelines and urinary cotinine levels by immunoassay. Pipe-years and cigar-years were calculated as years from self-reported age of starting to quitting (or to current age among current users) × pipefuls or cigars per day. Of 3,528 participants, 8% reported pipe smoking (median 15 pipe-years), 11% reported cigar smoking (median 6 cigar-years), and 52% reported cigarette smoking (median 18 pack-years). Self-reported current pipe and cigar smokers had elevated urinary cotinine levels compared to never smokers. Pipe-years were associated with decrements in the forced expiratory volume in one second (FEV1) and cigar-years were associated with decrements in the FEV1 and the ratio of the FEV1 to the forced vital capacity. Participants who smoked pipes or cigars had an increased odds of airflow obstruction whether they had also smoked cigarettes (Odds ratio 3.43; 95% CI: 1.75, 6.71; P<0.001) or had never smoked cigarettes (Odds ratio 2.31; 95% CI: 1.04, 5.11; P=0.039) compared to participants with no smoking history. Cross-sectional design. Pipe and cigar smoking increased urinary cotinine levels and was associated with decrements in lung function and increased odds of airflow obstruction, even among participants who never smoked cigarettes.
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影响因子：
9.6
作者：
Hankinson, John L.;Kawut, Steven M.;Barr, R. Graham
通讯作者：
Barr, R. Graham
影响因子：
8.3
作者：
DAYAL, HH;KHUDER, S;TRIEFF, N
通讯作者：
TRIEFF, N
影响因子：
9.6
作者：
Chapman, KR;Tashkin, DP;Pye, DJ
通讯作者：
Pye, DJ
影响因子：
5.3
作者：
Funck-Brentano, Christian;Raphael, Mathilde;Roussel, Ronan
通讯作者：
Roussel, Ronan
影响因子：
10
作者：
LANGE, P;GROTH, S;SCHNOHR, P
通讯作者：
SCHNOHR, P