The ash dieback invasion of Europe was founded by two genetically divergent individuals.
The ash dieback invasion of Europe was founded by two genetically divergent individuals.
复制标题
DOI：
10.1038/s41559-018-0548-9
复制
发表时间：
2018-06
影响因子：
16.8
通讯作者：
Clark MD
中科院分区：
文献类型：
--
作者：
McMullan M;Rafiqi M;Kaithakottil G;Clavijo BJ;Bilham L;Orton E;Percival-Alwyn L;Ward BJ;Edwards A;Saunders DGO;Garcia Accinelli G;Wright J;Verweij W;Koutsovoulos G;Yoshida K;Hosoya T;Williamson L;Jennings P;Ioos R;Husson C;Hietala AM;Vivian-Smith A;Solheim H;MaClean D;Fosker C;Hall N;Brown JKM;Swarbreck D;Blaxter M;Downie JA;Clark MD
国际贸易的加速和气候变化使病原体的传播日益受到关注。白蜡树枯梢病的致病因子是一种真菌病原体，它已经从亚洲的白蜡树传播到欧洲的白蜡树。大多数欧洲普通白蜡树（黄蜡树）对黄蜡树非常敏感，尽管少数（约5%）对枯死病有部分抗性。在这里，我们组装和注释了一个接近染色体规模的古蜥蜴草图基因组。欧洲和日本的病原体遗传多样性显示了欧洲的一个强大的瓶颈，尽管在关键的宿主相互作用基因中仍然存在适应性多样性的信号。我们发现欧洲种群是由两个不同的单倍体个体建立的。这些单倍型之间的差异代表了一个大的源群体中的祖先多态性。随后从这一来源引入将大大增加病原体的适应潜力。因此，拉克斯伊蚊进一步渗入欧洲是一种潜在的威胁，需要在全欧洲范围内采取生物安全措施来控制这种疾病。
Accelerating international trade and climate change make pathogen spread an increasing concern. Hymenoscyphus fraxineus, the causal agent of ash dieback, is a fungal pathogen that has been moving across continents and hosts from Asian to European ash. Most European common ash trees (Fraxinus excelsior) are highly susceptible to H. fraxineus, although a minority (~5%) have partial resistance to dieback. Here, we assemble and annotate a H. fraxineus draft genome which approaches chromosome scale. Pathogen genetic diversity across Europe and in Japan, reveals a strong bottleneck in Europe, though a signal of adaptive diversity remains in key host interaction genes. We find that the European population was founded by two divergent haploid individuals. Divergence between these haplotypes represents the ancestral polymorphism within a large source population. Subsequent introduction from this source would greatly increase adaptive potential of the pathogen. Thus, further introgression of H. fraxineus into Europe represents a potential threat and Europe-wide biological security measures are needed to manage this disease.
登录
查看更多内容
植物病原真菌核盘菌的完整基因组序列揭示了对广泛宿主范围病原体的基因组结构的见解。
影响因子：
3.3
作者：
Derbyshire M;Denton-Giles M;Hegedus D;Seifbarghy S;Rollins J;van Kan J;Seidl MF;Faino L;Mbengue M;Navaud O;Raffaele S;Hammond-Kosack K;Heard S;Oliver R
通讯作者：
Oliver R
影响因子：
2.7
作者：
Drenkhan, R.;Solheim, H.;Hietala, A. M.
通讯作者：
Hietala, A. M.
影响因子：
7.2
作者：
Fellbrich, G;Romanski, A;Nürnberger, T
通讯作者：
Nürnberger, T
影响因子：
9.4
作者：
Collemare, Jerome;Pianfetti, Mikael;Boehnert, Heidi U.
通讯作者：
Boehnert, Heidi U.
影响因子：
30.8
作者：
Burstein, David;Amaro, Francisco;Zusman, Tal;Lifshitz, Ziv;Cohen, Ofir;Gilbert, Jack A.;Pupko, Tal;Shuman, Howard A.;Segal, Gil
通讯作者：
Segal, Gil